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Collectively, we demonstrate that JMY enables p53-dependent DNA repair under genotoxic stress and suggest a role for actin in JMY nuclear activity during the DNA damage response.doi:10.1038/s41418-023-01170-9Rodriguez-Pastrana, IgnacioBirli, Eleni...
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Peposertib (M3814) is a potent and selective DNA-PK inhibitor in early clinical development. It effectively blocks non-homologous end-joining repair of DNA double-strand breaks (DSB) and strongly potentiates the antitumor effect of ionizing radiation (IR
regulated process of V(D)J recombination requires the introduction of site-specific DNA double-strand breaks in lymphocyte progenitors, and provides a useful model to study general mechanisms by which improper surveillance and repair of DSB might cause genomic instability and oncogenesis in vivo. V...
During this same period, <1% of prostatic glandular cells enter the S phase of the cell cycle, documenting that >95% of these die in G0. During the programmed death of these G0glandular cells, a futile DNA repair process is induced secondary to the DNA fragmentation. This futile DNA ...
Abundance and activity of p53 are predominantly regulated posttranslationally. Structural disturbance in transcribed genes induced by radiation, e.g. DNA damage, or by transcriptional inhibitors cause p53 protein stabilization by a yet unknown mechanism.
aSirt1 deacetylase activity has also been implicated in the repair of DNA damage, through its ability to deacetylate the tumor suppressor p53 [26,52], a sequence-specific transcription factor that regulates processes such as the cell cycle, cell death, and DNA repair, in response to a variety...
The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to ac...
Fig. 1: General overview of DNA damage response networks activate by DNA damage. Once cellular DNA damage occurs, the DDR is activated to protect damaged DNA integrity. The cell cycle is paused to provide cells an opportunity to activate DNA repair mechanisms. When the DNA damage is severe, ...