This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II interferons and many other cytokines signal through similar mechanisms. This well-understood pathway now serves as a paradigm showing how information from protein-protein contacts at the cell surface can...
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II ...
The JAK-STAT pathway at twenty. We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular ... G Stark,JD Jr - 《Immunity》 被引量: 1312发表: 2012年 Contribution of STAT SH2 groups to sp...
In this review, we aim to introduce the JAK-STAT pathway and its regulator proteins and elucidate the role of them in the differentiation of T helper(Th) cell subsets. Eventually, novel and approved therapeutic strategies are discussed in order to target the JAK-STAT pathway and its regulators...
E. Jr. The JAK-STAT pathway at twenty. Immunity 36, 503–514 (2012). This is a comprehensive overview including a historical perspective on the modulation of JAK–STAT signalling and its implications on cytokine biology. CAS PubMed PubMed Central Google Scholar Yoshimura, A., Naka, T. &...
Jr. The JAK-STAT pathway at twenty. Immunity 36, 503–514 (2012). Article CAS PubMed PubMed Central Google Scholar Darnell, J.E. Jr., Kerr, I.M. & Stark, G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science ...
Five cases also had mutations of JAK-STAT pathway-related genes at the same time. Though recurrent Chr9q gains were reported in mantle cell lymphoma(MCL), its frequency was lower, and the characteristic mutated genes in MCL were not related to the JAK-STAT pathway. These findings indicated ...
The JAK-STAT pathway presents an effective, reversible means of responding to many cell surface signals, to quickly alter transcription, and manipulate cellular processes like proliferation and apoptosis. Therefore, this pathway was important to investigate in the context of natural freeze-tolerance. ...
E. Jr. The JAK-STAT pathway at twenty. Immunity 36, 503–514 (2012). CAS PubMed PubMed Central Google Scholar Kim, E. et al. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell 23, 839–852 (...
E. Jr. The JAK–STAT pathway at twenty. Immunity 36, 503–514 (2012). Article CAS PubMed PubMed Central Google Scholar Wack, A., Terczyńska-Dyla, E. & Hartmann, R. Guarding the frontiers: the biology of type III interferons. Nat. Immunol. 16, 802–809 (2015). Article CAS Pub...