The chromatin in eukaryotic cells is not randomly organized, as various domains have been shown to occupy distinct ‘territories’ within the nucleus1,2,3,4. To decipher the chromatin architecture and three-dimensional (3D) organization within the nucleus, chromosome conformation capture techniques (...
b, Expression of known markers is shown using the same layout as in Fig. 1a (grey, no expression; yellow–red, relative expression). c, Heat maps show the subclasses of OPCs, astrocytes and microglia. The genes were organized into clusters. Top chart, gestational weeks. d, Immunostaining ...
that the patterned complexity of living systems is hierarchically organized and that higher levels in the hierarchy are characterized by the emergence of novelties; that observation and comparison are methods in biological research that are fully as scientific and heuristic as the experiment; that an i...
contig was approximately 62.59 Mb and the N50 was 46.86 Mb (Additional file1: Table S18). The contig-level assembly was then anchored into eight pseudo-chromosomes using the Hi-C data (Fig.5a; Additional file2: Fig. S20). The genome assembly of EDT exhibited a total size of 463.07 Mb ...
Genome Biol. 2016;17:29. Article PubMed PubMed Central Google Scholar Pelka K, Hofree M, Chen JH, Sarkizova S, Pirl JD, Jorgji V, et al. Spatially organized multicellular immune hubs in human colorectal cancer. Cell. 2021;184(18):4734–52 e20. Article CAS PubMed PubMed Central ...
The largest ever study of the genetics of the brain—encompassing some 36,000 brain scans—has identified more than 4,000 genetic variants linked to brain structure. The results of the study, led by researchers at the University of Cambridge, are publish
Nonetheless, our findings provided insights into the impact of milk microbiota on infant gut colonization and alternative means of supplementing probiotics to newborns.Availability of data and materials The whole-genome sequences of the four B. animalis subsp. lactis reference strains, namely M8, V9...
the human genome29. Minisatellites are tandem repetitions of more than 5 bp units, and their frequency in the human genome is relatively rarer than that of the former30. In the human genome, centromeric satellites can be classified into thealpha-satellite and Satellite II/III. Among them, ...
Human Acute Myeloid Leukemia Is Organized as a Hierarchy That Originates from a Primitive Hematopoietic Cell. Nat. Med. 1997, 3, 730–737. [Google Scholar] [CrossRef] Al-Hajj, M.; Wicha, M.S.; Benito-Hernandez, A.; Morrison, S.J.; Clarke, M.F. Prospective Identification of ...
The genotype is organized into N genes, each with an expression value—imagine a catalytic activity, for example—in the range of [−1.0,1.0][−1.0,1.0]. Each gene can interact with all other N genes, including itself, and these interaction weights are defined by a value from the ...