The total genetic complement of our species is called "human genome". It comprises a set of different DNA molecules, corresponding to 25 different types of chromosomes (22 autosomes, X chromosome, Y chromosome, mitochondrial DNA) which are present within our cells. All these DNA molecules are ...
The human genome comprises both our protein-coding genes and the regulatory information that controls when, and to what extent, those genes are expressed. While humans mostly share the same repertoire of genes and regulatory elements, the underlying sequences are as diverse as the people on Earth...
The human genome comprises of more than 2500 miRNAs, some of which are implicated in many diseases, including cancer7,8,9,10,11. The first link between cancer and miRNAs was discovered in 200212. Two miRNA genes were identified to be deleted in 50% of chronic lymphocytic leukemia (CLL) ...
A one-stop resource that provides the most frequently needed information on the human genome What are the genes that manke-up the human genome, what do the genes do when they are acting properly, and what happens when these genes are damaged? Designed for today's reader who demands quick ...
DNA comprises of four similar chemicals called bases (A, T, C, and G). In a genome, these bases are repeated millions or billions of times. The particular order of As, Ts, Cs, and Gs underlies all of life's diversifications and even determines whether an organism is human or another...
govern expression of targets throughout the genome (Fig.1). Genes and genetics of human Yq Although the first demonstration of the functional capacity of the NRY of the human Y chromosome was in 1997, the involvement of this locus with male infertility was first made almost four decades ago....
The repetitive fraction of the genome comprises diverse classes of repetitive DNA that is often polymorphic. Of these, the most recently discovered repeat-rich regions are those containing a high number of large-scale copy number variations (CNVs) [3] that involve the loss or gain of large ...
On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitously expressed in all human cells. Composition and prope
About 20% of the xMHC genes have putative paralogues elsewhere in the genome, indicating considerable potential for functional redundancy. The gene map of the xMHC provides an invaluable resource for the study of the most important genetic region of the human genome in relation to infectious, inf...
The third group comprises unique, single-copy DNA sequences, which do not share homology with any other sequences in the genome. Examples of such sequences in the human genome include protein-coding genes (e.g., theglobin,ovalbumin, andsilk fibroingenes), non-coding RNAs, and regulatory ele...