Molecular biology of the HPA axis. Handbook of Stress and the Brain - Part 1: The Neurobiology of Stress, 79-94. /Abel, K. B. and J. A. Majzoub. 2005. Molecular biology of the HPA axis. Handbook of Stress and the Brain. Vol. 15. Ch. 1.5....
Dysfunction of the hypothalamic–pituitary–adrenal (HPA)-axis has been observed in chronic alcoholics and in non-alcoholic sons of alcoholic parents, while genetic and environmental factors, such as stress, may play a significant role in the development of alcoholism. The present study was designed...
The hypothalamic-pituitary-adrenal (HPA) axis is normally quiescent during the stress-hyporesponsive period (SHRP) from day 4-14 in infant rats. However, m... MA Smith,Kim Su-Yong,van Oers Helga J. J.,... - 《Endocrinology》 被引量: 228发表: 1997年 Early maternal deprivation reduces ...
Although the mechanism is still unclear, SSRIs or various sedative drugs, including escitalopram, restore HPA axis function to normal in patients with generalised anxiety disorder and depression45,46. This process is presumed to be related to the restoration of the damaged barrier in patients with ...
The HPA axis also regulates the response to stress and various biological processes through the production of glucocorticoids (GCs) by the adrenal glands. GCs (cortisol in humans, corticosterone in rodents) regulate metabolism and immune response. To exclude the role of UVB-CGs on ILC2s, we meas...
HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender. . In sum, the stressor induced significant HPA axis responses in all age and gender groups. The observed ACTH response patterns in young and elderly ... BM ...
[449,450]. For that reason, Hegadorenet al. called attention to a possible role of β-END in the pathophysiology of major depression [337]. They reviewed the multiple interactive links between serotonin, β-END and the HPA-axis involved in major depression. Such interactions are of great ...
aIn conclusion, these results provide confirmation that the 6-hour cosyntropin stimulation test is a sensitive assay for distinguishing dose-related effects of prednisone on the HPA axis. This test also rules out clinically significant HPA-axis effects of FP ANS at up to four times the recommende...
(HPA) axis, the autonomic nervous system (ANS), the metabolic system as well as the immune system, produce physiological response. While these responses are adaptive in the short term, repeated exposure to adverse events or chronic stress can lead to long-lasting alterations in these systems. ...
we performed pathway analysis. Pathway analysis for differentially expressed genes 15 min after fear conditioning suggested upstream activation of hormone concentration, estrogen receptor 1 (Esr1) and dexamethasone-induced pathways with genes for receptors controlling the HPA axis and corticoids likeMc3r,...