The emerging nature of astrocyte diversity. Annu. Rev. Neurosci. 42, 187–207 (2019). CAS PubMed Google Scholar Zhan, J. S. et al. Astrocytes in migration. Neurochem. Res. 42, 272–282 (2017). ADS CAS PubMed Google Scholar Li, J. et al. Astrocyte-to-astrocyte contact and a ...
Screening 46 candidate genes for astrocyte diversity across the mouse cortex, we identified superficial, mid and deep astrocyte identities in gradient layer patterns that were distinct from those of neurons. Astrocyte layer features, established in the early postnatal cortex, mostly persisted in adult ...
We further show decreased microglia and astrocyte density in the hippocampus and increased microglial density in the prefrontal cortex. Together data suggests supraspinal glia is involved in the pathophysiology of nerve damage and related to mood disorders and cognitive impairment associated with nerve ...
The lack of effective understanding of the pain mechanism of McCune–Albright syndrome (MAS) has made the treatment of pain in this disease a difficult clinical challenge, and new therapeutic targets are urgently needed to address this dilemma. This pape
GFAP, NeuN, Iba-1, and Olig2 were stained to indicate astrocyte, neuron, microglia, and oligodendrocyte, respectively. (B) Localization of HDAC2 in different cell types, expressed as the proportion of co-labeled cells in total HDAC2-labeled cells. The cell number was counted from ...
Long non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that can regulate molecular and cellular processes in brain development and disease. LncRNAs exhibit cell type- and tissue-specific expression, but little is known about the expressio
The Emerging Nature of Astrocyte Diversity. Annu. Rev. Neurosci. 2019, 42, 187–207. [Google Scholar] [CrossRef] [PubMed] Chai, H.; Diaz-Castro, B.; Shigetomi, E.; Monte, E.; Octeau, J.C.; Yu, X.; Cohn, W.; Rajendran, P.S.; Vondriska, T.M.; Whitelegge, J.P.; et...
However, this drug has permeability issues, due to its hydrophilic nature, and, as a result, it crosses the BBB very poorly. A study was conducted in which SLNs of nitrendipine were prepared, and a comparison of the uptake of nano-formulation and the bulk drug was carried out. According ...
microenvironment, TAMs promote tumor progression. Here, we review the origin, heterogeneity, and functional roles of TAMs. In addition, we discuss the prospects of therapeutically targeting TAMs alone or in combination with standard or newly-emerging GBM targeting therapies....
Given its ubiquitous nature however, ATP could be released not only from neurons but also from non-neuronal cells in the nervous system. Therefore one of the most intriguing questions is to identify the source of ATP involved in the regulation of neuronal functions. Several neuronal pathways have...