The emerging nature of astrocyte diversity. Annu. Rev. Neurosci. 42, 187–207 (2019). Article CAS PubMed Google Scholar Khalilov, I., Minlebaev, M., Mukhtarov, M. & Khazipov, R. Dynamic changes from depolarizing to hyperpolarizing GABAergic actions during giant depolarizing potentials in ...
A transcriptomic cell-type atlas of the whole adult mouse brain with ~5,300 clusters built from single-cell and spatial transcriptomic datasets with more than eight million cells reveals remarkable cell type diversity across the brain and unique cell type characteristics of different brain regions. ...
Astrocyte-mediated inflammation is associated with degenerative pathologies such as Alzheimer’s and Parkinson’s diseases and multiple sclerosis
nucleotide and nucleoside receptors, ATP release channels, and nucleoside transporters. Because of its immunomodulatory function, this system is critically involved in the pathogenesis of multiple sclerosis (MS) and its best-characterized animal model, experimental autoimmune encephalomyelitis...
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Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res. 2000;60(5):1383–1387. 57. Pedersen MW, Meltorn M, Damstrup L, Poulsen HS.The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer...
diversity and acute radiation-induced enteropathy, as opposed to late enteropathy. The initial stages of enteropathy showed increased levels of microbiota-derived short-chain fatty acids (SCFAs), followed by a rise in the abundance of SCFA producers such asClostridium IV,Roseburia, andPhascolarcto...
S100A6 is involved in the regulation of cellular stress response. Cyp40, cyclophilin 40; Hop, Hsp90/Hsp70-organizing protein; Tom70, translocase of outer mitochondrial membrane70 Full size image S100A6 and cell differentiation The immense diversity of S100 family proteins proves that under various ...
perfectly explain the decline in T-cell receptor (TCR) diversity in humans.43,44 One of the hallmarks of immunosenescence is “inflammaging,” which refers to a systemic state of chronic low-grade inflammation characterized by upregulated blood inflammatory markers and is considered the central ...
A. et al. Environmental control of astrocyte pathogenic activities in CNS inflammation. Cell 176, 581–596 (2019). CAS PubMed PubMed Central Google Scholar Shan, B. et al. The metabolic ER stress sensor IRE1alpha suppresses alternative activation of macrophages and impairs energy expenditure ...