The emerging hallmarks of cancer metabolism. Cell Metab. 2016;23(1):27–47. Article CAS PubMed PubMed Central Google Scholar Cai L, Sutter BM, Li B, Tu BP. Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Mol Cell. 2011;42(4)...
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate Cancer Cell (2012) N.N. Pavlova et al. The emerging hallmarks of Cancer metabolism Cell Metab. (2016)View more references Cited by (16) GlcA-mediated glycerol-3-phosphate synthesis contributes to the oxidation resistance ...
B. The emerging hallmarks of cancer metabolism. Cell Metab. 23, 27–47 (2016). CAS PubMed PubMed Central Google Scholar Heiden, M. G. V., Cantley, L. C. & Thompson, C. B. Understanding the warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029–1033 (...
1). First, we briefly introduce the changes in glucose, lipid, and amino acid metabolism in cancer cells. Then, we discussed the regulatory effects of DNA methylation, histone modification, chromatin remodeling, and noncoding RNA on metabolic reprogramming in tumor cells. Finally, we discuss the...
Trends in Endocrinology and MetabolismDonohoe CL, Lysaght J, O'Sullivan J, Reynolds JV. Emerging concepts linking obesity with the hallmarks of cancer. Trends Endocrinol Metab. 2017; 28:46-62.DONOHOE CL, LYSAGHT J, O'SULLIVAN J, et al. Emerging con- cepts linking obesity with the hallmarks...
Aberrant proliferation of cancer cells is supported by enhanced adaptation to nutrient microenvironment mediated by alterations in energy metabolism. Consequently, metabolic reprogramming is believed to be one of the hallmarks of tumor cells in parallel with genomic instability, tumor-provoking chronic inflam...
Emerging role of cancer stem cells in the biology and treatment of ovarian cancer: basic knowledge and therapeutic possibilities for an innovative approachReview Open access Published: 01 August 2013 Volume 32, article number 48, (2013) Cite this article ...
of this concept (2), deregulating cellular etabolism and avoiding immune destruction were segregated as “emerging hallmarks,” but now, eleven years later, it is evident that they, much like the original six, can be considered core hallmarks of cancer, and are included as such in the ...
The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer. Increased evidence suggests that cancer metabolism not only plays a crucial role in cancer signaling for sustaining tumorigenesis and survival, but also has wider impli...
Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list - reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ...