Article 1: "The Hallmarks of Cancer: The Next Generation" (癌症的标志物:新一代) This article, translated as "The Next Generation of Cancer Hallmarks," is a comprehensive review of theoriginal hallmarks of cancer proposed by Hanahan and Weinberg in 2000. The authors, Li and Wang, take a ...
Robert A. Weinberg. Hallmarks of Cancer: The Next Generation. Cell. 2011; 144(5): 646-674. 3 Douglas Hanahan. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022; 12: 31-46. 4 https://zhuanlan.zhihu.com/p/458126180
十年之后的2011年,两位教授根据十年间对肿瘤研究的最新进展和研究范式的更迭,与时俱进地对原来的6大癌症标志性特征进行了更新和拓展,撰写的“Hallmarks of cancer: the next generation”仍旧发表在Cell杂志上,目前已被引用超过57000次。 十年如烟,转瞬即逝,如今2022年的第三版“Hallmarks of Cancer”正式发布,而作...
DNA Methylation in Healthy Tissues and Early Studies in Cancer 健康组织中的DNA甲基化及癌症早期研究 para 在人类中,被最深研究的表观遗传标记是DNA甲基化。 DNA甲基化是指在胞嘧啶核苷酸上添加一个甲基基团(CH3)作为共价修饰,几乎只发生在人类中,位于碱基鸟嘌呤之前的胞嘧啶,即CpG二核苷酸。 由于其主要是稳定...
Hallmarks of Cancer Immunoresistance (The Lancet Oncology review article: De-novo and acquired resistance to immune checkpoint targeting. 2017;18:e731–e741)Syn, Nicholas
Volume 39, pages 625–645, (2020) Cite this article Cancer and Metastasis Reviews Aims and scope Submit manuscript Zheng Zhong, Jia Yu, David M. Virshup & Babita Madan 9815 Accesses 4 Altmetric Explore all metrics Abstract Since the discovery of the first mammalian Wnt proto-oncogene in ...
Radiotherapy is used in the treatment of approximately 50% of all malignancies including gastrointestinal cancers. Radiation can be given prior to surgery (neoadjuvant radiotherapy) to shrink the tumour or after surgery to kill any remaining cancer cells
"The Hallmarks of Cancer" is a seminalpeer-reviewed article published in the journal Cell in January 2000 by the cancer researchers Douglas Hanahan and Robert Weinberg. The authors believe that the complexity of cancer can be reduced to a small number of underlying principles. The paper argues ...
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2022年1月,Douglas Hanahan教授在Cancer Discovery杂志发表了第3版“Hallmarks of Cancer:new dimensions”,再增加了4个新的肿瘤标志性特征,分别是:解锁表型可塑性(unlocking phenotypic plasticity)、衰老细胞(senescent cells)、非突变表观遗传重编程(non-mutational epigenetic reprogramming)及多态性的微生物组(polymorphic...