Valanne, Susanna, Jing-Huan Wang, and Mika Ramet. 2011. ―The Drosophila Toll Signaling Pathway.‖ Journal of Immunology (Baltimore, Md. : 1950) 186 (2): 649-56. doi:10.4049/jimmunol.1002302.Valanne, S., Wang, J.H., Ramet, M., 2011. The Drosophila Toll signaling pathway. J. ...
Through genetic studies, Tube, Pelle, Cactus, and Dif have been identified as downstream components of the Toll-1 signaling pathway. Here we report characterization of a Drosophila homologue of human MyD88, dMyD88. We show that dMyD88 is an adapter in the Toll signaling pathway that ...
molitor larvae. In systemically infected insect models, Gram-positive bacterial infections are mostly regulated by the Toll signaling pathway, but in the gut-specific immune responses in Drosophila, the IMD pathway is implicated for the clearance of Gram-positive bacteria S...
The Toll signaling pathway, which is required for the establishment of the dorsal–ventral axis in Drosophila embryos, plays an important role in the response of larval and adult Drosophila to microbial infections. Recent genetic evidence has shown that a mammalian Toll-like receptor, mouse Tlr4, ...
TollPelleTubeIn Drosophila, the Toll pathway establishes the embryonic dorsoventral axis and triggers innate immune responses to infection. The transmembrane receptor Toll acts through three death domain-containing proteins, the kinase Pelle and the adapters Tube and MyD88, in signaling to downstream ...
A conserved signaling pathway: the Drosophila Toll-Dorsal pathway Annu. Rev. Cell Dev. Biol., 12 (1996), pp. 393-416 CrossrefView in ScopusGoogle Scholar Benjamini and Hochberg, 1995 Y. Benjamini, Y. Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple...
The human homologue ofDrosophilaToll (hToll) is a recently cloned receptor of the interleukin 1 receptor (IL-1R) superfamily, and has been implicated in the activation of adaptive immunity. Signaling by hToll is shown to occur through sequential recruitment of the adapter molecule MyD88 and the...
receptors (PRRs), the Toll-like receptor signaling pathway, the MyD88- dependent pathway, endogenous ligands, immune effectors, antimicrobial peptides, apoptosis, and adaptation-related transcripts. Among PRRs, we conducted detailed in silico characterization of TLR-2, CTL, and PGRP_SC2-like. ...
摘要: Focuses on the establishment of the dorsal-ventral pattern of the Drosophila embryo by three sequential signaling pathways. Signaling from the oocyte to surrounding follicle cells; Maternal pathway establishing the dorsal-ventral pattern of the embryo; Role of zygotically active genes....
Steward, R. Dorsal, an embryonic polarity gene inDrosophila, is homologous to the vertebrate proto-oncogene, c-rel. Science 238, 692–694 (1987). ArticleCASADSGoogle Scholar Belvin, M. P. & Anderson, K. V. A conserved signaling pathway: theDrosophilatoll-dorsal pathway. Annu. Rev. Cell ...