The Toll-Dorsal pathway in Drosophila and the interleukin-1 receptor (IL-1R)-NF-魏B pathway in mammals are homologous signal transduction pathways that mediate several different biological responses. In Drosophila, genetic analysis of dorsal-ventral patterning of the embryo has defined the series of...
Drosophila Toll and IL-1 receptor Nature. 1991 May 30;351(6325):355-6. Comparative Study; Letter NJ Gay,FJ Keith - 《Nature》 被引量: 2628发表: 1991年 A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of...
The Toll-Dorsal pathway in Drosophila and the interleukin-1 receptor (IL-1R)-NF-kappa B pathway in mammals are homologous signal transduction pathways that... MP Belvin,KV Anderson - 《Annu Rev Cell Dev Biol》 被引量: 2404发表: 1996年 Functional interactions between the pelle kinase, Toll ...
Sas is a ligand that binds the receptor tyrosine phosphatase Ptp10D. Typically, Sas/Ptp10D interact at the apical surface of epithelial cells. However, at the interface between scrib−/− cells and neighbouring wild-type cells, they relocate to the lateral membrane where they engage in trans...
Here we report the identification of a new mutant allele of DmMyD88 , which generates a protein lacking the carboxy-terminal extension, normally located downstream of the Toll/IL-1 receptor domain. Homozygous mutant female flies lay dorsalized embryos that are rescued by expression of a ...
The abbreviations used are: LRR, leucine-rich repeat; TLR, Toll-like receptor; IL, interleukin; TIR, Toll/IL-1 receptor domain; C106, dimer of C-terminal 106 amino acids of Spätzle; EGF, epidermal growth factor; FGF, fibroblast growth factor; NGF, nerve growth factor; ITC, isothermal ...
The Drosophila Toll receptor is crucial for dorsoventral patterning in embryos, and for innate immunity. Toll also functions during central nervous system ... McIlroy,G William - 《University of Birmingham》 被引量: 0发表: 2012年 Identification of interleukin-1 receptor-associated kinase 1 as a...
Like Drosophila Toll, human Toll is a type I transmembrane protein with an extracellular domain consisting of a leucine-rich repeat (LRR) domain, and a cytoplasmic domain homologous to the cytoplasmic domain of the human interleukin (IL)-1 receptor. Both Drosophila Toll and the IL-1 receptor ...
Drosophila mounts a potent host defence when challenged by various microorganisms. Analysis of this defence by molecular genetics has now provided a global picture of the mechanisms by which this insect senses infection, discriminates between various cla
Examining the insulin signaling pathways downstream of the insulin receptor, similar yet intriguing results were obtained. dAkt expression was elevated in the aging controlDrosophilafrom day 10 to day 30 (Fig.2d; p < 0.01). At day 30, supplementation with Lp8826, TFLA and the synbiotic ...