Toll-like receptorsEndotoxin toleranceThe Toll-IL-1 receptor (TIR) superfamily, defined by the presence of an intracellular TIR domain, initiates innate immunity via NF-魏B activation, leading to production of proinflammatory cytokines. ST2 is a member of the TIR family that does not activate NF...
A decade ago, pharmacological experiments showed that elevated brain levels of the anti-inflammatory molecule IL-1 receptor antagonist reduced seizures in epilepsy models. This observation, together with the evidence of in situ induction of inflammatory mediators and their receptors in experimental and ...
Toll-Like Receptor 4 and Toll-IL-1 Receptor Domain-Containing Adapter Protein (TIRAP)/Myeloid Differentiation Protein 88 Adapter-Like (Mal) Contribute to Maximal IL-6 Expression in Macrophages Previous studies have shown that engagement of Toll-like receptors (TLR) 2 and 4 can induce macrophages ...
TLR1/2H/MCell surfaceAc3LP, glycolipids, triacyllipopeptidesreceptors for lipopeptides TLR2/6H/MCell surfaceAc2LP, LTA, zymosan, peptidoglycan, ciacyllipopeptidesreceptors for lipopeptides TLR3H/MEndosomepolyI:C, dsRNA(reovirus), RSV, MCMVstimulates IFN-α/β and IL-12p70 production ...
Toll-like receptors (TLRs) are pattern recognition receptors that trigger innate immunity. In this study we investigated the expression of 10 TLRs in human... NL Bernasconi,N Onai,A Lanzavecchia - 《Blood》 被引量: 1259发表: 2003年 The Contribution of the Toll-Like/IL-1 Receptor Superfamily...
Toll-like receptors (TLRs) are members of the IL-1 receptor superfamily, and comprise a family of molecules that detect and facilitate responses to a broad range of bacterial and viral pathogens. Additional roles for these receptors in disease may include the detection of tissue damage at inflamm...
Toll-like receptors are key mediators of immune responses, but gaps remain in understanding their signalling. Here, the authors introduce an optical biosensor assay to detect real-time TLR activation and signalling dynamics, uncovering signalling signatures that may aid future drug design. ...
Dinarello, C.A. The biological properties of interleukin-1.Eur. Cytokine Netw.5, 517–531 (1994). CASGoogle Scholar O'Neill, L.A. & Dinarello, C.A. The IL-1 receptor/Toll-like receptor superfamily: crucial receptors for inflammation and host defense.Immunol. Today21, 206–209 (2000)...
Interleukin-17A (IL-17A)-producing CD4(+) T helper (Th17) cells have been shown to be essential for defense against pulmonary infection with Coccidioides species. However, we have just begun to identify the required pattern recognition receptors and understand the signal pathways that lead to Th17...
Toll-like receptors (TLRs) have an extracellular region, which contains leucine-rich repeat motifs, and a cytoplasmic tail, which has a Toll/interleukin-1(IL-1) receptor (TIR) domain. Different TLRs recognize different surface and intracellular components of microorganisms. The interaction between a...