signalingreceptortlrsliketlrpathways VIEWPOINT Toll-LikeReceptorSignalingPathways GregoryM.BartonandRuslanMedzhitov* MembersoftheToll-likereceptor(TLR)familyrecognizeconservedmicrobialstruc- tures,suchasbacteriallipopolysaccharideandviraldouble-strandedRNA,and activatesignalingpathwaysthatresultinimmuneresponsesagainstmicrobia...
Toll-Like Receptor Signaling PathwaysPathway, View FullVersion, Request Print
stimulatedindividualTLRfamilymembers.AllTLRsactivatecommonsignalingpath-waynuclearfactor–B(NF-B)transcriptionfactors,mitogen-activatedproteinkinases(MAPKs)extracellularsignal–regulatedkinase(ERK),p38,c-JunN-terminalkinaseJNK)[seeTLRpathwayproximaleventssignalingpathwaydepend,teractionsbetweenmodularsignalingdomains.One...
(LPS) of Gram-negative bacteria and stimulates the synthesis and release of inflammatory cytokines through activation of the NF-κB signaling pathway,which ultimately results in inflammatory responses that involve multiple organs.Animal and clinical studies have shown that the TLR4 signal pathway plays ...
A. et al. IKKε and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491–496 (2003). Article CAS PubMed Google Scholar Tan, Y. & Kagan, J. C. Innate immune signaling organelles display natural and programmable signaling flexibility. Cell 177, 384–398 (...
In contrast, the MyD88 death domain is required for NF-κB activation and survival. These studies identify a novel MyD88-dependent PI-3 kinase signaling pathway in T cells that differentiates CpG DNA mediated proliferation from survival. ^ 展开 年份: 2006 ...
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nature Cell Biol. 2, 346–351 (2000). Article CAS PubMed Google Scholar Zhang, G. & Ghosh, S. Negative regulation of Toll-like receptor-mediated signaling by Tollip. J. Biol. Chem. 277, 7059–7065...
As it can be seen from this chapter, structural genomic variation in Toll-like receptor signaling pathway may be also associated with cancer; however, there are only a few studies devoted to the problem. In contrast to polymorphisms of genes encoding TLRs, whose association with solid tumors is...
Regional modulation of toll‐like receptor signaling pathway genes in acute epididymitis in mice Background: Region‐specific immune environments in the epididymis influence the immune responses to uropathogenic Escherichia coli (UPEC) infection, a rel... AD Andrade,PGC Almeida,NAP Mariani,... - 《...
TIRAP: an adapter molecule in the Toll signaling pathway. Nature Immunol. 2, 835–841 (2001). Article CAS Google Scholar Fitzgerald, K. A. et al. Mal (MyD88-adaptor-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78–83 (2001). Article CAS PubMed Google...