Circular RNAs (circRNAs) are a novel class of RNAs distinguished by their single-stranded, covalently-closed topology. Although initially perceived as rare byproducts of aberrant splicing, circRNAs are now recognized as ubiquitously expressed and functionally significant. These discoveries have led to a...
How can advanced methods for the design, synthesis, purification, and delivery of circRNA-based therapies be developed to enhance their clinical translation? Introduction Cancer is a significant global health challenge, annually claiming millions of lives [1]. The emergence of immunotherapy has ushered...
Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by specific cis-acting elements and trans-acting factors. Some circRNAs are ab
Such a requirement imposes a limitation in that it is impossible to design multiple RNAi molecules with distinct coverages to exclude potential off-target effects. Moreover, the partial complementarity of a half-RNAi sequence (∼10 nt) to its cognate linear RNA may have an effect on the ...
Noncoding RNAs such as circular RNAs (circRNAs) are abundant in the human body and influence the occurrence and development of various diseases. Non-small cell lung cancer (NSCLC) is one of the most common malignant cancers. Information on the functions
which are necessary for eliciting powerful and lasting neutralizing antibody responses, especially against viruses that escape humoral immunity [204]. Any advancement in our knowledge of the kinetics of the GC reaction and the differentiation of the TFH cell will undoubtedly assist the design of future...
This interaction can serve as an opportunity to design targeted therapies inhibiting the activated pathways in patients with NF2 (discussed in "Future therapeutic perspective" Section). Merlin structure The NF2 gene expresses ten different isoforms resulting from alternative splicing, among which isoforms ...
or other forms to prepare prodrugs. Carbonyl-containing drugs can be prepared using a Schiff base, oxime, acetal, or ketal, among other methods. Jing Lanlan et al. investigated the design and synthesis of the A11 prodrug Chuanxiongzine, an anti-ischaemic stroke drug, and discovered that it ex...
2.0 provides a new design of arRNA that enables more precise, efficient RNA editing with broad applicability for therapy and basic research. This is a preview of subscription content,access via your institution Access options Access Nature and 54 other Nature Portfolio journals...
Circular RNAs (circRNAs) are a regulatory RNA class. While cancer-driving functions have been identified for single circRNAs, how they modulate gene expression in cancer is not well understood. We investigate circRNA expression in the pediatric malignanc