The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. Oncogene. 2014;33:4685-96.Sparks A, Dayal S, Das J, Robertson P, Menendez S, Saville MK. 2014. The degradation of p53 and its major E3 ligase Mdm2 is differentially...
In addition, they could be exploited for p53-activating therapies. This work shows that the degradation of proteins by the proteasome can be selectively dependent on S5a in human cells, and that this selectivity can extend to an E3 ubiquitin ligase and its substrate. Oncogene (2014) 33, 4685...
The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest and apoptosis, in response to various types of stress1. The activity of p53 is abrogated by mutations that occur frequently in tumours, as well as by several vira
The interval between p53 activation and consequent Mdm2 accumulation defines a time window during which p53 exerts its effects. We now report that Mdm2 also promotes the rapid degradation of p53 under conditions in which p53 is otherwise stabilized. This effect of Mdm2 requires binding of p53; ...
or epigenetic changes in breast cancer as described in the text. Not shown is the induction of MDM2, which acts as a negative feedback regulator of the pathway by promoting the degradation of p53. Because of space limitations, other important constituents of the pathway have had to be omitted...
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 1990;63:1129–36. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2175676 Article CAS PubMed Google Scholar Werness BA, Levine AJ, ...
For example, phosphorylation increases the stability of p53 protein, which reduces the degradation of p53 protein by its negative regulation protein mdm2 and hence results in the elevation of p53 protein level in cells [2], [5], [6]. Increasing documents have suggested that translational control...
Since p53 has important functions over the regulation of the cellular cycle, proliferation, and apoptosis, it is subject to strict regulation. The degradation of p53 occurs in the proteasome, and depends on its ubiquitination by Mdm2 (murine double minute 2). Hyperglycemia affects the concentration...
Sunitinib-induced autophagic degradation of p53 is involved in its low anti-cancer activity [118]. It has been reported that p53 can mediate autophagy by facilitating the free beclin 1 from the Bcl-2-Bcl-xL-beclin 1 complex by repressing transcription of Bcl-2, Bcl-xL, and Mcl-1 [[119]...
Thus the p53 status of GC-2 cells influenced the membrane expression of Fas, subsequently influencing the degradation of the anti-apoptotic protein c-FLIP (L). In summary, the results indicate that p53 promotes Fas activated germ cell apoptosis in response to MEHP-induced Sertoli cell injury, ...