The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. Oncogene. 2014;33:4685-96.Sparks A, Dayal S, Das J, Robertson P, Menendez S, Saville MK. 2014. The degradation of p53 and its major E3 ligase Mdm2 is differentially...
We now report that Mdm2 also promotes the rapid degradation of p53 under conditions in which p53 is otherwise stabilized. This effect of Mdm2 requires binding of p53; moreover, a small domain of p53, encompassing the Mdm2-binding site, confers Mdm2-dependent detstabilization upon heterologous ...
proteins. Raised amounts of Mdm2 strongly repress mutant p53 accumulation in tumour-derived cells. During recovery from DNA damage, maximal Mdm2 induction coincides with rapid p53 loss. We propose that the Mdm2-promoted degradation of p53 provides a new mechanism to ensure effective termination of t...
Considerable efforts have been expended to explore strategies to therapeutically target mutant p53 in cancer cells. These strategies include promoting the degradation of mutant p53 proteins through proteasomal or autophagy pathways (Fig. 4A), restoring WT p53 function in mutant p53 proteins in cancer ce...
The interval between p53 activation and consequent Mdm2 accumulation defines a time window during which p53 exerts its effects. We now report that Mdm2 also promotes the rapid degradation of p53 under conditions in which p53 is otherwise stabilized. This effect of Mdm2 requires binding of p53; ...
Many of the components of this signalling pathway are targets for genetic and/or epigenetic changes in breast cancer as described in the text. Not shown is the induction of MDM2, which acts as a negative feedback regulator of the pathway by promoting the degradation of p53. Because of space...
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 1990;63:1129–36. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2175676 Article CAS PubMed Google Scholar Werness BA, Levine AJ, ...
Cell type:A31N-ts20 Abstract Protein degradation is an essential and highly regulated process. The proteasomal degradation of the tumor suppressors p53 and p73 is regulated by both polyubiquitination and by an ubiquitin-independent process. Here, we show that this ubiquitin-independent process is medi...
Mdm2 promotes the rapid degradation of p53 Nature, 387 (1997), pp. 296-299, 10.1038/387296a0 View in ScopusGoogle Scholar Herzog et al., 1998 K.-H. Herzog, M.J. Chong, M. Kapsetaki, J.I. Morgan, P.J. McKinnon Requirement for atm in ionizing radiation-induced cell death in the ...
Sunitinib-induced autophagic degradation of p53 is involved in its low anti-cancer activity [118]. It has been reported that p53 can mediate autophagy by facilitating the free beclin 1 from the Bcl-2-Bcl-xL-beclin 1 complex by repressing transcription of Bcl-2, Bcl-xL, and Mcl-1 [[119]...