Reports that the Mdm2 oncoprotein promotes the rapid degradation of p53 tumor-suppressor protein, under conditions in which p53 is otherwise stabilized. The The process of recovery from DNA damage; The proposal of a new mechanism to ensure effective termination of the p53 signal.HauptYgalMayaRuthNatureNature
The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest and apoptosis, in response to various types of stress1. The activity of p53 is abrogated by mutations that occur frequently in tumours, as well as by several vira
proteins. Raised amounts of Mdm2 strongly repress mutant p53 accumulation in tumour-derived cells. During recovery from DNA damage, maximal Mdm2 induction coincides with rapid p53 loss. We propose that the Mdm2-promoted degradation of p53 provides a new mechanism to ensure effective termination of t...
Mdm2 promotes the rapid degradation of p53 Nature, 387 (1997), pp. 296-299 View in ScopusGoogle Scholar 17 A. Hershko Roles of ubiquitin-mediated proteolysis in cell cycle control Curr. Opin. Cell Biol, 9 (1997), pp. 788-799 View PDFView articleView in ScopusGoogle Scholar 18 R. Honda...
Mdm2 promotes the rapid degradation of p53. Nature 1997; 387(6630):296–299. Article PubMed CAS Google Scholar Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature 1997; 387(6630):299–303. Article PubMed CAS Google Scholar Michael D, Oren M. The p53-...
Mdm2 promotes the rapid degradation of p53 Nature, 387 (1997), pp. 296-299 View in ScopusGoogle Scholar 3 J.D. Oliner, J.A. Pietenpol, S. Thiagalingam, J. Gyuris, K.W. Kinzler, B. Vogelstein Oncoprotein MDM2 conceals the activation domain of tumor suppressor p53 Nature, 362 (1993...
Mdm2 promotes the rapid degradation of p53. Nature. 1997;387:296–9. 50. Rodriguez MS, Desterro JM, Lain S, Lane DP, Hay RT. Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. Mol Cell Biol. 2000;20:8458–67. 51. Momand J, Zambetti GP, ...
Mdm2 promotes the rapid degradation of p53. Nature. 1997 Jun 19;387(6630):296-9. 2. Marine JC, Jochemsen AG. Mdmx as an essential regulator of p53 activity. Biochem Biophys Res Commun. 2005 Feb 11;331(3):750-60. 3. Shvarts A, Steegenga WT, Riteco N, van Laar T, Dekker P, ...
Mdm2 promotes the rapid degradation of p53. Nature 1997; 387: 296–299. 35. Lai Z, Ferry KV, Diamond MA, Wee KE, Kim YB, Ma J et al. Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization. J Biol Chem 2001; 276: 3135...
Oncoprotein Mdm2 is ubiquitin ligase E3 for tumour suppressor p53. FEBS Lett. 420, 25–27 (1997). Article CAS PubMed Google Scholar Haupt, Y., Maya, R., Kazaz, A. & Oren, M. Mdm2 promotes the rapid degradation of p53. Nature 387, 296–299 (1997). Article CAS PubMed Google ...