Restoration of p53 activity through inhibiting the interaction between p53 and MDM2 represents a promising approach for cancer therapy. A number of small-molecule p53–MDM2 binding inhibitors have been developed during the past several years. Nutlin-3 has shown a potent and selective small-molecule ...
How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures. ChemMedChem 2016, 11 (8), 757-772.Estrada‑Ortiza N, Neochoritisa CG and Dömlinga A: How to design a successful p53‑MDM2/X interaction inhibitor: A thorough ...
A simplified model depicting the mechanism how MDM2 inhibits Axin-induced p53 activation.Ying HeGuili LianShuyong LinZhiyun YeQinxi Li