DEAD-box RNA helicases comprise a family within helicase superfamily 2 and make up the largest group of RNA helicases. They are a profoundly conserved family of RNA-binding proteins, carrying a generic Asp–Glu–Ala–Asp (D–E–A–D) motif that gives the family its name. Members of the...
The DEAD-box protein family of RNA helicases. Gene 367, 17–37 (2006). CAS PubMed Google Scholar Jarmoskaite, I. & Russell, R. DEAD-box proteins as RNA helicases and chaperones. Wiley Interdiscip.Rev. RNA 2, 135–152 (2011). CAS PubMed PubMed Central Google Scholar Abdelhaleem,...
RNA helicases of the DEAD-box protein family all have nine characteristic motifs. These motifs clearly distinguish this family from other, highly related, RNA helicase families such as the DEAH-box or the Ski2 families. The motifs are contained within a core domain that is flanked by less-co...
Members of the DEAD-box family of RNA helicases are engaged in all facets of RNA metabolism from biogenesis to decay. DEAD-box proteins ordinarily function as constituents of enormous multi-protein complexes and it is believed that interactions with other components in the complexes might be ...
The presence of the eight conserved motifs characteristic of the DEAD protein family was observed in the T. cruzi sequence, indicating that it corresponds to a putative RNA helicase gene, which we named HelTc. Southern blot analysis indicated that HelTc is a single-copy gene. Pulsed-field gel...
Background p68 (Ddx5) and p72 (Ddx17) are highly related members of the DEAD box family and are established RNA helicases. They have been implicated in growth regulation and have been shown to be involved in both pre-mRNA and pre-rRNA processing. More recently, however, these proteins hav...
Also ddx-23, which encodes a DEAD box protein homolgous to the yeast splicing factor PRP28 was found to be required for the sperm/oocyte switch [23]. DEAH and DEAD box proteins belong to the DExD/H RNA helicase family, which play many roles in RNA metabolism, for example, pre-mRNA...
The K-homology (KH) domain is a nucleic acid-binding domain present in many proteins but has not been reported in helicases. DDX43, also known as HAGE (helicase antigen gene), is a member of the DEAD-box protein family. It contains a helicase core domain in its C terminus and a ...
Over the last 3 decades, the DEAD-box RNA helicase (RH) family proteins have been isolated from a wide range of organisms from viruses to E. coli to humans [1]. Their mechanisms of action, functional diversity, regulation and potential targets for disease treatment have gradually emerged over...
The genetic regulation of cell cycle progression and cell proliferation plays a role in the growth of non-small cell lung cancer (NSCLC), one of the most common causes of cancer-related mortality. Although DEAD-box RNA helicases are known to play a role in cancer development, including lung...