DEAD-box RNA helicases comprise a family within helicase superfamily 2 and make up the largest group of RNA helicases. They are a profoundly conserved family of RNA-binding proteins, carrying a generic Asp–Glu–Ala–Asp (D–E–A–D) motif that gives the family its name. Members of the...
The DEAD-box protein family of RNA helicases. Gene 367, 17–37 (2006). CAS PubMed Google Scholar Jarmoskaite, I. & Russell, R. DEAD-box proteins as RNA helicases and chaperones. Wiley Interdiscip.Rev. RNA 2, 135–152 (2011). CAS PubMed PubMed Central Google Scholar Abdelhaleem,...
Over the last 3 decades, the DEAD-box RNA helicase (RH) family proteins have been isolated from a wide range of organisms from viruses to E. coli to humans [1]. Their mechanisms of action, functional diversity, regulation and potential targets for disease treatment have gradually emerged over...
RNA helicases of the DEAD-box protein family all have nine characteristic motifs. These motifs clearly distinguish this family from other, highly related, RNA helicase families such as the DEAH-box or the Ski2 families. The motifs are contained within a core domain that is flanked by less-co...
Using Saccharomyces cerevisiae as a model organism, we have identified a member of the DEAD-box protein (DBP) family, the DEAD-box RNA helicase and mRNA export factor Dbp5, as a player in translation termination. Dbp5 interacts genetically with both release factors and the polyadenlyate-...
4) DEAD-box RNA helicase DEAD盒解旋酶 1. Molecular characterization of a rice DEAD-box RNA helicase gene OsBIRH1 and purification of recombinant protein; 预测的OsBIRH1蛋白包含DEAD盒解旋酶所特有的保守DEAD和HELICc结构域以及保守模体结构。
DEAD-boxRNA helicases, characterized by a highly conserved “Asp-Glu-Ala-Asp” (DEAD) motif, are found in all eukaryotes, as well as in many bacteria andarchaea[72]. DEAD-boxRNAhelicases form the largest family of superfamily 2 (SF2) helicases, with 37 members in humans[72]. This fam...
RNA helicases of the DEAD box family are present in all eukaryotic cells and in many bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism from transcription to degradation and are therefore important players in gene expression. DEAD box proteins use ATP to unwind sh...
DEAD-box RNA helicases comprise a family within helicase superfamily 2 and make up the largest group of RNA helicases. They are a profoundly conserved family of RNA-binding proteins, carrying a generic Asp–Glu–Ala–Asp (D–E–A–D) motif that gives the family its name. Members of the...
DEAD-box proteins form the largest family of RNA helicases and are conserved from bacteria to humans. They belong to superfamily 2 (SF2) of RNA helicases which harbor an Asp-Glu-Ala-Asp (DEAD) motif that defines the family.1DEAD-box RNA helicases are central players in RNA biology and ...