In this review, we first summarize the protein structure, cellular distribution, and diverse biological functions of DEAD-box RNA helicases. Then, we discuss the distinct roles of DEAD-box RNA helicase family in CRC and describe the cellular mechanism of actions based on ...
The functions of the DEAD-box helicase family have been extensively studied, including their roles in liver cancer [6,7], pancreatic cancer [8,9], breast cancer [10], and gastrointestinal tumors [11,12]. Notably, a substantial proportion of research focuses on the involvement of this protein...
The DEAD-box protein family of RNA helicases. Gene 367, 17–37 (2006). CAS PubMed Google Scholar Jarmoskaite, I. & Russell, R. DEAD-box proteins as RNA helicases and chaperones. Wiley Interdiscip.Rev. RNA 2, 135–152 (2011). CAS PubMed PubMed Central Google Scholar Abdelhaleem,...
DEAD/H-box蛋白家族是哺乳动物中最大的RNA解旋酶家族,在RNA代谢、DNA转录、核糖体生物发生、细胞增殖和凋亡等方面发挥着重要作用。既往的研究表明DEAD/H-box解旋酶家族成员中既有促癌又有抑癌基因。由于在乳腺癌及妇产科肿瘤中的异常表达,DEAD/H-box解旋酶家族参与了肿瘤的发生发展。本文主要就DEAD/H-box解旋酶家...
DEAD-box RNA helicases, characterized by a highly conserved “Asp-Glu-Ala-Asp” (DEAD) motif, are found in all eukaryotes, as well as in many bacteria and archaea [72]. DEAD-box RNA helicases form the largest family of superfamily 2 (SF2) helicases, with 37 members in humans [72]....
Actually, the DEAD-box protein family was discovered on the basis of conserved sequence motifs of eIF4A. Motif II (or Walker B motif) has the amino acids D-E-A-D (Asp-Glu-Ala-Asp), which gave the name to the family. In general, the eIF4A is considered as a helicase that locally...
RNA helicases of the DEAD-box protein family all have nine characteristic motifs. These motifs clearly distinguish this family from other, highly related, RNA helicase families such as the DEAH-box or the Ski2 families. The motifs are contained within a core domain that is flanked by less-co...
DEAD-box RNA helicase Escherichia coli Ribosome assembly mRNA degradation Translation initiation Cold-adaptation 1. Introduction DEAD-box proteins are ubiquitous enzymes that use ATP to rearrange RNA and RNA–protein structures. They consist of a helicase core containing 12 conserved motifs involved in ...
Abstract: The normal occurrence and maturation of sperm require the correct expression of many relevant genes. Therefore, the mRNA transcription of these genes requires better stability to maintain their translation activity. The DEAD-box protein family is an ATP-dependent RNA helicase family involving...
DExD/H-box RNA helicases belong to the RNA-binding protein (RBP) family and are the largest consortium of RNA helicases, ubiquitously present across diverse organisms41. Their pivotal functions encompass remodeling RNA structures by harnessing the energy derived from ATP hydrolysis, thereby influenci...