box helicase family proteins; their roles in digestive system cancers, including their relationships with clinical factors; effects on cancer proliferation, migration, and invasion; and involved signaling pathways; as well as the existing inhibitory strategies targeting DDX family proteins, are discussed....
RNA helicases of the DEAD box family are important players in RNA metabolism in most living organisms. Despite high conservation between DEAD box proteins, they participate in many different processes. Recent structural and functional analyses have changed our perception of these fascinating enzymes. Th...
the mRNA transcription of these genes requires better stability to maintain their translation activity. The DEAD-box protein family is an ATP-dependent RNA helicase family involving a variety of RNA metabolic processes such as RNA secondary structure transformation, transcription...
艾普蒂生物提供参考文献: 1. Fuller-Pace FV. RNA helicases: Modulators of RNA structure. Trends Cell Biol. 1994;4(8):271-275. 2. Linder P, Jankowsky E. From unwinding to clamping - the DEAD box RNA helicase family. Nat Rev Mol Cell Biol. 2011;12(8):505-516. 3. Yang YC, Chiang...
Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog 来自 Wiley 喜欢 0 阅读量: 51 作者:H Sato,H Oshiumi,H Takaki,H Hikono,T Seya 摘要: Viral RNA represents a pattern molecule that can be recognized by RNA sensors in innate immunity. Humans and mice ...
Actually, the DEAD-box protein family was discovered on the basis of conserved sequence motifs of eIF4A. Motif II (or Walker B motif) has the amino acids D-E-A-D (Asp-Glu-Ala-Asp), which gave the name to the family. In general, the eIF4A is considered as a helicase that locally...
DEAD-box家族1. DEAD-box family proteins are a putative ATP-dependent RNA helicase, which form a widely dispersed family of proteins ranging from viruses to mammals, and are associated with nearly all RNA processes. DEAD-box家族蛋白是一类ATP依赖的RNA解旋酶,广泛存在于从细菌到哺乳动物的许多物种...
By analyzing CRC genomic data from The Cancer Genome Atlas (TCGA) [10], we demonstrated for the first time the frequent gain of copy number of DEAD-box helicase 27 (DDX27) in CRC. DDX27 belongs to the DEAD box nucleic acid helicase family, which is characterized by a conserved “DEAD-...
RNA helicases of the DEAD box family are present in all eukaryotic cells and in many bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism from transcription to degradation and are therefore important players in gene expression. DEAD box proteins use ATP to unwind sh...
Yang Q., Jankowsky, E. 2006. The DEAD-box protein Ded1 unwinds RNA duplexes by a mode distinct from translocating helicases. CAS CASPubMedGoogle Scholar Lund M.K., Guthrie C. 2005. The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim.Mo...