DEAD-box家族蛋白RNA解旋酶癌症靶向治疗DEAD-box家族蛋白是一类ATP依赖的RNA解旋酶,在RNA代谢的过程中发挥重要的作用.DEAD-box家族蛋白可通过调节癌基因和抑癌基因的表达及肿瘤相关信号通路等影响细胞的增殖,分化,凋亡,进而发挥促癌或抑癌的作用.%DEAD-box family protein is a kind of ATP dependent RNA helicase,...
DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoanLeishmania.We show that genetic inactivatio...
The mechanism of ATP-dependent RNA unwinding by DEAD-box proteins. Biol. Chem. 390, 1237–1250 (2009). CAS PubMed Google Scholar Strohmeier, J., Hertel, I., Diederichsen, U., Rudolph, M. G. & Klostermeier, D. Changing nucleotide specificity of the DEAD-box helicase Hera abrogates ...
DEAD-box RNA解旋酶参与RNA转录、前体mRNA剪切、核糖体发生、核质运输、蛋白质翻译、RNA降解等重要的生命活动。 2. The DEAD-box RNA helicases is a big ATP-dependent RNA helicases family, which originates from a wide range of organisms ranging from prokaryotes, including viruses, to eukaryotes such ...
Abstract: The normal occurrence and maturation of sperm require the correct expression of many relevant genes. Therefore, the mRNA transcription of these genes requires better stability to maintain their translation activity. The DEAD-box protein family is an ATP-dependent RNA helicase family involving...
DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoanLeishmania.We show that genetic inactivatio...
Many of these DEAD-box proteins (but not all) have been shown to have RNA-dependent ATPase and ATP-dependent RNA helicase activities. Many of them have also been shown to contain DNA unwinding activities. Translation initiation factor 4A is the prototype of the DEAD-box family of proteins. ...
DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoanLeishmania.We show that genetic inactivatio...
For this reason, RNA helicases are increasingly thought of as ATP-dependent translocases or as RNA chaperones that are used to ensure the correct folding, or refolding, of RNA molecules Lorsch 2002, Mohr et al. 2002, Tanner and Linder 2001. The largest family of RNA helicases is the DEAD...
中文名称: DEAD box protein 3, X-chromosomal 中文同义词: ANTI-DDX3 ANTIBODY-三磷酸腺苷依赖解旋酶DDX3抗体 英文名称: DEAD box protein 3, X-chromosomal 英文同义词: ANTI-DDX3(C-TERMINAL) antibody produced in rabbit;ATP-dependent RNA helicase DDX3X;DBX;DDX3;DDX3X;DEAD box protein 3, X-chromo...