DEAD-box RNA解旋酶(RH) OsRH37 超表达 RNAi 亚细胞定位DEAD-box RNA解旋酶(RNA helicase,RH)普遍存在于绝大多数的生物体中,参与到RNA新陈代谢的各个方面。本研究从日本晴水稻(Oryza sativa L.japonica.cv.Nipponbare)叶片RNA中成功克隆DEAD-box RNA解旋酶基因Os RH37的CDS全长序列。序列比对发现,Os RH37的...
DEAD-box RNA解旋酶(DEAD-box helicase, DDX)是一类ATP依赖的RNA解旋酶,其功能是调控RNA代谢的各个方面,包括转录、剪切、转出、翻译、核糖体合成及miRNA调控,进而参与肿瘤增殖、肿瘤凋亡、肿瘤侵袭和转移、肿瘤耐药和肿瘤免疫治疗等多种过程。DDX21是DDX家族蛋白重要成员,可在多种肿瘤组织中异常表达,对肿瘤的发生、...
3.1.1DEAD-box RNA helicases The majority of all proteins identified as components ofRNPgranules in oocytes contain RNA-binding domains, and several DEAD-boxRNAhelicases localize to oocyte RNPs.DEAD-box RNA helicasesmay perform generally in large RNP particles as RNA chaperones or architectural fact...
2022年7月7日,中国药科大学孔令义及张浩共同通讯在Hepatology在线发表题为“RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling”的研究论文,该研究发现发现 DDX5 在 NASH 患者和小鼠模型的肝脏以及棕榈酸 (PA) 刺激的肝细...
DEADboxRNAhelicasefunctionsincancer FrancesV.Fuller-Pace Divisiono,CancerResearch;Universityo,Dundee;NinewellsHospitalandMedicalSchool;Dundee,Scotland Keywords:DEADbox(multi)unctionalRNAhelicases(cancer)oncogene,tumorsuppressor Memberso,theDEADbox,amilyo,RNAhelicasesareknowntobeinvolvedinmostcellularprocessesthatrequi...
DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoanLeishmania.We show that genetic inactivatio...
DEAD-box RNA helicases are involved in various aspects of RNA metabolism, including RNA transcription, premRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation and RNA decay. DEAD-box RNA解旋酶参与RNA转录、前体mRNA剪切、核糖体发生、核质运输、蛋白质翻译、RNA降解等重要的生命活动。
DEAD-box RNA helicaseGlycine-rich RNA-binding proteinMain conclusion This work demonstrated that a cold-induced DEAD-box RNA helicase, CbDRH, is also post-transcriptionally regulated upon cold stress, and it interacts with a cold-responsive, glycine-rich, RNA-binding protein, CbGRP. Chorispora ...
The review summarizes a current knowledge about a role of RNA helicases in the development and maintenance of gamenogenesis in eukaryotes. We focused on th
DEAD-box RNA helicases; cancer; DDX3X; DDX5; oncogene; oncosuppressor1. Introduction The DEAD-box RNA helicase family is a class of enzymes that belongs to the helicase superfamily 2 [1]. Due to the presence of a characteristic Asp-Glu-Ala-Asp (DEAD) motif, DEAD-box proteins have been...