With respect to molecular pathogenesis, the Wnt/-catenin, TGF-signaling routes, aPKC-i/P-Sp1/Snail Signaling, B7-H1/PD-1Pathway and Fas/FasL signaling pathways are connected to the malignant potential and contributed to tumor immune evasion by increasing TIL apoptosis. Distinct subtypes of TILs...
Expression of bcl-2 oncoprotein in atypical adenomatous hyperplasia of the lung. In press. Shimosato Y, Kodama T . Low grade malignant and benign tumors. Current problems. In: McDowell EM, editor. Tumor pathology: lung carcinomas. Edinburgh: Churchill Livingstone; 1987. p. 310–29. Google ...
Cancer stem cells (CSCs) are a small subpopulation of malignant tumor cells characterized by tumorigenic properties and the ability to self-renew and form differentiated progeny, which can be characterized by several markers such as aldehyde dehydrogenase (ALDH), CD44 and CD133 [157, 158]. CSCs ...
Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing technology represents a significant breakthrough in personalized immunotherapy for human cancer. This strategy uses genetic modification to enable T cells to target tumor-specific antigens, attack specific cancer cells,...
Mechanistically, the FOXA family of transcription factors maintains enhancer activity and nucleosome localization by opening chromatin structures; thus, they are known as pioneer factors [5, 10, 11]. FOXA1 and FOXA2 play different biological functions in tumor development by regulating the expression ...
Objective: To analyze the characteristics of growing Breast Imaging Reporting and Data System (BI-RADS) category 3 lesions and malignant tumors during breast ultrasound follow-up. Methods: From November 2018 to November 2021, 115 patients with growing BI-RADS 3 lesions were followed up. The patien...
Several previous studies demonstrated that the combination of self-expandable metallic stents (SEMS) and 125I seed implantation might prolong stent patency and obtain survival benefits for malignant obstructive jaundice (MOJ) patients. However, these studies rarely mentioned a comparison between CT-guided...
These areas are often the sites of tumor recurrence. Therefore, peritumoral edema is one of the main biological characteristics of glioma, which has an important impact on clinical prognosis and is associated with a high disability rate and high mortality rate [27]. Studies have shown that ...
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx s
Ladanyi, A. et al. FOXP3+ cell density in primary tumor has no prognostic impact in patients with cutaneous malignant melanoma. Pathol. Oncol. Res. 16, 303–309 (2010). PubMed Google Scholar Mahmoud, S. M. et al. An evaluation of the clinical significance of FOXP3+ infiltrating cells...