The hormone responsiveness and tissue specific functions have been, however, suc cessfully maintained in organ cultures...Peehl DM, Wong ST, Bazinet M, Stamey TA (1989): In vitro studies of human prostatic epithelial cells: attempts to identify distinguishing features of malignant cells. Growth ...
摘要: Radionuclide imaging techniques were used to indicate the location and incidence of bone metastases in 30 dogs with malignant mammary tumors. The method was successful in distinguishing mammary tumor metastases in the sternum of one dog.关键词:...
Deciphering the role of plasma proteins in pancreatic cancer (PC) susceptibility can aid in identifying novel targets for diagnosis and treatment. We examined the relationship between genetically determined levels of plasma proteins and PC through a syst
To identify the immune cells affected by smoking, we use single-cell RNA sequencing on peripheral blood from smokers and nonsmokers. Transcriptomes reveal a subpopulation of FCGR3A (CD16)-expressing natural killer (NK)-like CD8 T lymphocytes that increase in smokers. Mass cytometry confirms ...
Here, we composed a tissue microarray (TMA) consisting of 149 PPGLs, reflecting clinical features, presenting as a useful resource. Mutations in the pseudohypoxic marker HIF-2α correlate to an aggressive tumor phenotype. We show that HIF-2α localized to the cytoplasm in PPGLs. This sub...
Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors that accounts for approximately 70% of all embryonal CNS tumors in the age group of 0–19 years [47]. Standard-of-care therapy including surgical resection of the tumor, cytotoxic chemotherapy, and cranio-spinal ...
Minichromosome Maintenance Complex Component 4 (MCM4) is a vital component of the mini-chromosome maintenance complex family, crucial for initiating the replication of eukaryotic genomes. Recently, there has been a growing interest in investigating the s
We validated this hypothesis in a large-scale study of patients with 13 different autoimmune, allergic, infectious, malignant, endocrine, metabolic, and cardiovascular diseases, as well as a therapeutic study of the mouse arthritis model. Conclusions Overall, our results support that our strategy has...
We thank A. Abate, A. Bhaduri, A. Tward and B. Tomlin for comments and reagents; K. Probst and N. Sirivansanti for illustrations; A. Shai and the staff of the UCSF Brain Tumor Center Biorepository and Pathology Core; T. Ozawa and the staff of the UCSF Brain Tumor Center Preclinical...
Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CRISPR dropout screen and integrate analyses of the mult...