A malignant phyllodes tumor contains heterologous stromal elements, and can transform into rhabdomyosarcoma, liposarcoma and osteosarcoma. These versatile properties prompted us to explore their possible relationship to mesenchymal stem cells (MSCs) and to search for the presence of cancer stem cells (...
Deciphering the role of plasma proteins in pancreatic cancer (PC) susceptibility can aid in identifying novel targets for diagnosis and treatment. We examined the relationship between genetically determined levels of plasma proteins and PC through a syst
Whether immune checkpoint inhibition, alone or in combination, is able to achieve long-term responses in advanced and metastatic ccRCC, similar to the responses observed in malignant melanoma, will emerge in the future. First studies also indicated that a multi-peptide vaccine was beneficial in ...
Here, we composed a tissue microarray (TMA) consisting of 149 PPGLs, reflecting clinical features, presenting as a useful resource. Mutations in the pseudohypoxic marker HIF-2α correlate to an aggressive tumor phenotype. We show that HIF-2α localized to the cytoplasm in PPGLs. This sub...
Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CRISPR dropout screen and integrate analyses of the mult...
Characterization of the interstitial fluid perfusing the breast tumor microenvironment: a novel resource for biomarker and therapeutic target discovery Mol. Cell. Proteomics, 3 (2004), pp. 327-344 View in ScopusGoogle Scholar 15 Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F.H.,...
Bone morphogenetic protein 4 (BMP4) plays an important role in cancer pathogenesis. In breast cancer, it reduces proliferation and increases migration in a cell line-dependent manner. To characterize the transcriptional mediators of these phenotypes, we
Overall, this study identified that METTL3 high status, is associated with poor prognosis and HPV status, and serves as a mediator of the immunosuppressive tumor microenvironment in HPV-associated cancer, which provides a promising therapeutic target for anti-cancer immunotherapy....
Nowadays, rapid development of “-omic” technologies, including gene chip analysis and next-generation sequencing, has been proven to generate vast volumes of molecular data for a tumor and publicly stored in databases for assessment of differentially expressed genes (DEGs) in a tumor without the ...
We thank A. Abate, A. Bhaduri, A. Tward and B. Tomlin for comments and reagents; K. Probst and N. Sirivansanti for illustrations; A. Shai and the staff of the UCSF Brain Tumor Center Biorepository and Pathology Core; T. Ozawa and the staff of the UCSF Brain Tumor Center Preclinical...