此外,WPH干预后,Th1/Th2平衡恢复、IgA分泌增加,肠道有益菌数量增加、产生有益SCFAs、促进肠道免疫耐受,最终食物过敏症状得到缓解。该研究结果可能为缓解乳清蛋白食物过敏提供潜在的预防策略。 Abstract Whey protein, a by-product of chees...
Chapter 2Th1/Th2 Cell Differentiationand Molecular SignalsYuan Zhang, Yaguang Zhang, Wangpeng Gu and Bing SunAbstract The distinctive differentiated states of the CD4+ T helper cells are deter-minedbythesetoftranscriptionfactorsandthegenestranscribedbythetranscriptionfactors. In vitro induction models, ...
Interleukin-23 (IL-23) is a key cytokine in Th17 cell differentiation. The aim of this study was to explore the function of IL-23 in determining the distribution of Th lymphocyte subsets (Th1, Th2, and Th17) after RSV infection in vitro. Human bronchial epithelial cell line BEAS-2B was...
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DC 诱导的Thl 样反应减弱LFA—l 和ICAM—l 通路诱导 Thl 极化是非IL—l2 依赖性的,可能通过ERK 途径? Rogers 等进一步研究了共刺激分子(CD28,OX40, LFA—l,CIM),抗原剂量与Thl/Th2 细胞分化的关系.作者 提出以下模式:低/中等剂量抗原伴多个共刺激分子相互作 用或大剂量抗原伴少数协同刺激分子辅助作用...
然而,在IBD发病机制中GPR65在调节CD4+T细胞免疫反应的潜在作用仍不完全清楚。同济大学炎症性肠病研究中心刘占举教授团队于今年3月在Clin Transl Med期刊上发表的题为GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation ...
2 and IL-2 receptor. The differentiation of Th1 cells and Th2 cells depends on the cytokines they are exposed to. IL-12 causes Th1 differentiation and blocks Th2 cell production (see “IL12 and Stat4 Dependent Signaling Pathway in Th1 Development” pathway), while IL-4 causes Th2 ...
In contrast, deletion of Gata3 prevents differentiation into the Th2 lineage and overexpression in Th1 cells switches their polarity to a Th2 phenotype6,7. Our understanding of how T-bet and GATA3 function to regulate the Th1/Th2 cell fate decision mostly stems from the murine Ifng and Il...
Intracellular detection of T-cell cytokines. Differentiation of TH1 and TH2 cellsThe use of cytometry has become very important in different fields of modern biology and medicine (1-4). In addition to the simple measurement of cell ... U Banning,D Körholz - 《Methods Mol Biol》 被引量...
These results support the hypothesis that the presence or absence of specific transcription factors is not the only parameter that determines Th1 and Th2 phenotypes. Moreover, the signaling requirement to induce AP-1 transcriptional activity is also reprogrammed during the differentiation of pTh cells ...