SB525334是一种有效的,选择性的TGFβ receptor I (ALK5)抑制剂,IC50为14.3 nM,作用于ALK4比作用于ALK5效果低4倍,可抑制ALK2, 3,和6活性。A potent ATP-competitive inhibitor against receptor TbR-I/ALK5. SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3...
Such phosphorylation by MAPKs in the Smad3 linker region is reportedly required for the full activation of Smad signaling.38,39 For example, inhibition of p38MAPK by the specific inhibitor SB202190 interferes with stimulatory effects of exogenous TGFb2 on migration of cells and on production of ...
Importantly, we observed that treatment with 50 mM of the TGFb receptor inhibitor, SB431542, significantly suppressed the BEC differentiation of YAP 5SA over- expressing hepatoblasts (Fig. 4e) and slightly restored the expression levels of Hnf4a and Cyp7a1 in hepatocytes over- expressing the ...
The concentration of bile acid in serum also markedly reduced with the treatment of FexD; however, it was to some extent blocked by the TGFBRI inhibitor SB431542 (Figure 2(c)). HE staining of the colon evaluated the histological changes. DSS treatment caused muscle thickening, crypt damage,...
相关产品:SB-431542 | Dorsomorphin | A 83-01 | LDN193189 | RepSox | SB 525334 | DMH-1 | SB-505124 | BMP signaling agonist sb4 | GW788388 | ITD-1 | LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA) | SD-208 | LDN-212854 | K02288 | LDN-214117 | R-268712 | SM 16 | A 77...
LY294002, a P13-kinase inhibitor, blocked this induced migration and phosphorylation of AKT. Inhibitors of TGFβRI (SB43 1524) and Smad3 (SIS3) blocked TGFβ isoform induced motility and TGFβ isoform induced pAKT^473. There was no differential isoform effect on the phosphorylation of ERK ...
The indicated cells were lysed in radioimmunoprecipitation assay buffer (RIPA, Beyotime, China) supplemented with protease and phosphatase inhibitor cocktail (Epizyme, China). Bicinchoninic acid assay (BCA, Biosharp, China) was used to detect protein concentration. The proteins were separated using 10%...
相关产品:SB-431542 | Dorsomorphin | A 83-01 | LDN193189 | RepSox | SB 525334 | DMH-1 | SB-505124 | BMP signaling agonist sb4 | ITD-1 | GW788388 | LSKL, Inhibitor of Thrombospondin (TSP-1) | LDN-212854 | K02288 | SD-208 | LDN-214117 | R-268712 | SM 16 | A 77-01 | ...
To examine the contribution of transactivation dependent pathways in LPA mediated GAG chain synthesizing gene expression, we utilised specific TGFBR1 inhibitor, SB431542 (3 μM) and EGFR antagonist, AG1478 (5 μM). LPA treatment stimulated a 2.8-fold (p < 0.01) change of XYLT1 expression (...
D, SCP25 cells were pretreated with 10 μM TGFb type I receptor (TbRI) inhibitor (SB431542) or vehicle (DMSO) for 30 minutes and then stimulated with TGFb. Total cell lysates were analyzed for p21 and b-tubulin protein levels by Western blotting. E, MDA cells were transfected with 40 ...