产品描述ITD-1 is an inducer of TGFβ type II receptor degradation-1, is a potent and highly selective TGFβ pathway inhibitor (IC50=0.85μM). 信号通路TGF-beta/Smad 靶点TGFβ--- IC500.85μM--- 体外研究ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes...
产品描述 ITD-1 is an inducer of TGFβ type II receptor degradation-1, is a potent and highly selective TGFβ pathway inhibitor (IC50=0.85μM). 信号通路 TGF-beta/Smad 靶点 TGFβ - - - - IC50 0.85μM - - - - 体外研究 ITD-1 selectively enhances the differentiation of uncommitted mesode...
TGF-beta 2/1.2TGF-beta 3TGF-beta 1, 2, 3TGF-beta 5 TGF-beta Family Receptors - Products by Molecule ALK-1ALK-7CD109CriptoEndoglin/CD105MIS RII TGF-beta RI/ALK-5TGF-beta RIITGF-beta RIIITGF-beta Receptor Inhibitors TGF-beta Family Signaling Modulators - Products by Molecule ...
相较于TGF-β途径胞内复杂的信号转导途径,该通路的守门员-TGFBR1/2是作为靶标最好的选择。 表1: TGF-β receptor的部分抑制剂(数据来源:药渡) 综上所述,TGFBR在多种恶性肿瘤如胰腺癌中展现出作为治疗靶标的巨大潜力。一项关于Galunisertib的临床研究揭示,抑制TGF-β通路能够显著影响肿瘤微环境,并引发上皮-间...
另有研究表明在缺失TGF-β信号通路所依赖的TGF-β receptor I-III,以及缺少smad1或smad5的小鼠中,普遍会出现血管黑内皮细胞的缺陷。由此可见依赖于smad和TGF-β信号通路异常一定程度上可以通过血供的加强,促进肿瘤的发生发展。 早在19世纪苏格...
产品描述 ITD-1 is an inducer of TGFβ type II receptor degradation-1, is a potent and highly selective TGFβ pathway inhibitor (IC50=0.85μM). 信号通路 TGF-beta/Smad 靶点 TGFβ - - - - IC50 0.85μM - - - - 体外研究 ITD-1 selectively enhances the differentiation of uncommitted...
表1: TGF-β receptor的部分抑制剂(数据来源:药渡) 综上所述,TGFBR在包括胰腺癌在内的多种恶性肿瘤中展现出了作为潜在治疗靶标的巨大前景。一项关于Galunisertib的临床研究显示,抑制TGF-β通路能够显著改变肿瘤微环境,并对上皮间质转化(EMT)和免疫功能等产生微妙而重要的影响[7]。这一发现强调了进一步探索TGF-...
[5] Yan, X. et al. (2011). Smad7: not only a regulator, but also across-talk mediator of TGF-beta signalling. Biochem J 434, 1-10. [6] Tsukazaki, T., et al. (1998). SARA, a FYVE domain protein thatrecruits Smad2 to the ...
产品描述 ITD-1 is an inducer of TGFβ type II receptor degradation-1, is a potent and highly selective TGFβ pathway inhibitor (IC50=0.85μM). 信号通路 TGF-beta/Smad 靶点 TGFβ - - - - IC50 0.85μM - - - - 体外研究 ITD-1 selectively enhances the differentiation of uncommitted...
No.: HY-12704CAS No.: 1099644-42-4分式: CHNO分量: 415.52作靶点: TGF- Receptor作通路: TGF-beta/Smad储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 28 mg/mL (67.39 mM; Need ultrasonic and war 2、ming)H2O : 40% PEG300 5% ...