PROBLEM TO BE SOLVED: To provide antagonistic peptides that inhibit binding of TGFβ1 to a transformation growth factor(TGFβ1) receptor.EZQUERRO SAENZ IGNACIO JOSEエスケルロ サエンス,イグナシオ ホセLASARTE SAGASTIBELZA JUAN JOSEラサルテ サガスティベルサ,フアン ホセPRIETO VALTUENA JESUS...
Introduction to the TGF-beta Superfamily Activins and Inhibins Activins and Inhibins - Products by Molecule Activin AActivin ABActivin ACActivin BActivin CC17orf99 INHBAINHBBInhibinInhibin AInhibin B Activin Receptors - Products by Molelcule ...
Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-β type I receptor kinase in puromycin-induced nephritis. Grygielko et al. J.Pharmacol.Exp.Ther., 2005;313:943 Inhibition of AVNreceptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis ...
TGF-β还可以诱导其他非SMAD信号传导途径,包括通过上游介导子RhoA、Ras激活几种MKKs(MAP kinase Kinase)和MEKs(MAPK/ERK Kinase)途径(JNK/SPAK,p38和ERK1/2)。TAK1(TGF-Beta Activated Kinase)、TAB1(TAK1 Binding Protein)和蛋白XIAP(Xenopus Inhibitor of Apoptosis),HPK1(Haematopoietic Progenitor Kinase-1)也...
Solubility: Soluble to 100 mM in DMSO Purity: ≥98% Storage: Store at -20°C CAS No: 614749-78-9 The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. Tocris products are intended for laboratory research use only, unless stat...
Galunisertib (LY2157299) is a TGF-β receptor type I (TGF-βRI) inhibitor (IC50=56 nM) that is selective. Galunisertib has antitumor activity and can be used in combination with PD-1 inhibitors. TGF-beta/Smad $40 In Stock Size ...
ALK5 Inhibitor IV, A8301 T3031909910-43-6 A 83-01 (ALK5 Inhibitor IV) 是一种 TGF-βI 型受体 ALK5、ALK4 和 ALK7 的抑制剂 (IC50=12/45/7.5 nM)。A 83-01 可促进小鼠成纤维细胞重编程为 iPSCs。A 83-01 可用于类器官培养。
LY2157299是有效的TGFβ receptor I (TβRI)抑制剂,IC50为56 nM。Phase 2/3。A potent TGF beta RI inhibitor. LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2/3. A potent TGF beta RI inhibitor. ...
TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice Abnormal accumulation of the amyloid-beta peptide (Abeta) in the brain appears crucial to pathogenesis in all forms of Alzheimer disease (AD), but the unde... T Wyss-Coray,C Lin,F Yan,... -...
产品编号 T2109 别名SD208, ALK5 Inhibitor VCas号 627536-09-8 SD-208 (ALK5 Inhibitor V) 是 TGF-βRI (ALK5) 的选择性抑制剂(IC50:48 nM),对其选择性是对 TGF-βRII 的 100 多倍。 规格价格库存数量 1 mg ¥ 177 现货 5 mg ¥ 392 现货 10 mg ¥ 633 现货 25 mg ¥ 1,280...