recruit Smad2 and Smad3 for phosphorylation by the TGF-β receptor. cPML issequestered in the nucleus by the homeodomain protein TGIF (TG-interactingfactor), a negative regulator of TGF-β signaling. Recently, PCTA (PML competitorfor TGIF association) has been shown to compete with cPML for ...
除了直接诱导或抑制靶基因表达外,TGF-βα还诱导多种复杂的细胞反应,具体取决于细胞类型,其中最显著的是涉及PI3K(Phosphatidylinositol-3-Kinase)和PP2A(Protein Phosphatase-2A)的G1晚期的生长停滞、分化程序的变化和凋亡(参考文献3)。其他生长因子也可以通过Ras的GRB2(Growth Factor Receptor-Bound Protein-2)-SOS激活...
The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid ...
转移生长因子β受体3抗体(TGF beta Receptor III) 价格: ￥980/支 产品详情:科淼生物简介温州科淼生物科技有限公司(Whenzhou KeMiao Biological Technology Co.,Ltd)是一家专业从事“产品研发生产,市场销... 纯度:1mg/ml% 包装规格:50ul 用途:仅供科研使用 用途:仅供科研使用 货号:KMA022122R 品牌:KEMOBio 生...
转移生长因子β受体2抗体(TGF beta Receptor II) 价格: ￥980/支 产品详情:科淼生物简介温州科淼生物科技有限公司(Whenzhou KeMiao Biological Technology Co.,Ltd)是一家专业从事“产品研发生产,市场销... 纯度:1mg/ml% 包装规格:50ul 用途:仅供科研使用 用途:仅供科研使用 货号:KMA021329R 品牌:KEMOBio 生长...
中文名称:Anti-TGF beta Receptor I antibody-转移生长因子β受体1抗体英文名称:TGF beta Receptor I 品牌:沪震生物产地:中国/上海 保存条件:-20°C纯度规格:> 99% 产品类别:抗体 一抗 抗体名:TGF-beta receptor type-1; TGFBR1; TGF Beta R1; AAT 5; AAT5; Activin A receptor type II like kinase 53...
其他生长因子也可以通过Ras的GRB2(Growth Factor Receptor-Bound Protein-2)-SOS激活来调节TGF-β介导的信号传导。 TGF-β可能是最多效性的分泌蛋白,其作为形态发生子,介导包括血液生成、激素分泌的调控、免疫应答、血管生成、组织形态发生和再生以及骨诱导和调节在内的几种生理过程。关于骨诱导,TGF-β诱导肌肉组织...
LY2157299是有效的TGFβ receptor I (TβRI)抑制剂,IC50为56 nM。Phase 2/3。A potent TGF beta RI inhibitor. LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2/3. A potent TGF beta RI inhibitor. ...
中文名称:Anti-TGF beta Receptor III antibody -转移生长因子β受体3抗体 英文名称:TGF beta Receptor III 纯度:> 99% 包装信息:50ul/RMB 1098;100ul/RMB 1880;200ul/RMB 2900 备注:Beta glycan; TGF Beta R3; Betaglycan; Betaglycan proteoglycan; BGCAN; TGF beta receptor type 3; TGF-beta receptor ...
DNA encoding TGF-β type III receptor of mammalian origin, DNA encoding TGF-β type II receptor of mammalian origin, TGF-β type III receptor, TGF-β type II receptor and uses therefor.Lin, Herbert Y.Wang, Xiao-fanWeinberg, Robert A....