Introduction to the TGF-beta Superfamily Activins and Inhibins Activins and Inhibins - Products by Molecule Activin AActivin ABActivin ACActivin BActivin CC17orf99 INHBAINHBBInhibinInhibin AInhibin B Activin Receptors - Products by Molelcule ...
A 83-01 (ALK5 Inhibitor IV) 是一种 TGF-βI 型受体 ALK5、ALK4 和 ALK7 的抑制剂 (IC50=12/45/7.5 nM)。A 83-01 可促进小鼠成纤维细胞重编程为 iPSCs。A 83-01 可用于类器官培养。 ALKTGF-beta/Smad ¥ 285 现货 规格 数量 客户已引用 ...
TGF-β还可以诱导其他非SMAD信号传导途径,包括通过上游介导子RhoA、Ras激活几种MKKs(MAP kinase Kinase)和MEKs(MAPK/ERK Kinase)途径(JNK/SPAK,p38和ERK1/2)。TAK1(TGF-Beta Activated Kinase)、TAB1(TAK1 Binding Protein)和蛋白XIAP(Xenopus Inhibitor of Apoptosis),HPK1(Haematopoietic Progenitor Kinase-1)也...
LY2157299是有效的TGFβ receptor I (TβRI)抑制剂,IC50为56 nM。Phase 2/3。A potent TGF beta RI inhibitor. LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2/3. A potent TGF beta RI inhibitor. ...
Purity: ≥98% Storage: Store at -20°C CAS No: 614749-78-9 The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. Tocris products are intended for laboratory research use only, unless stated otherwise. ...
Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-β type I receptor kinase in puromycin-induced nephritis. Grygielko et al. J.Pharmacol.Exp.Ther., 2005;313:943 Inhibition of AVNreceptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis ...
产品编号 T2109 别名SD208, ALK5 Inhibitor VCas号 627536-09-8 SD-208 (ALK5 Inhibitor V) 是 TGF-βRI (ALK5) 的选择性抑制剂(IC50:48 nM),对其选择性是对 TGF-βRII 的 100 多倍。 规格价格库存数量 1 mg ¥ 177 现货 5 mg ¥ 392 现货 10 mg ¥ 633 现货 25 mg ¥ 1,280...
In certain embodiments, the compounds disclosed herein can be used in the treatment of diseases by inhibiting TGF-β and blocking TGF-β signaling.ラジンダーシントッドキンセラジアシンユーマリーナジェルマンイハブエスダーウィッシュ
TGF-beta / Smad signaling pathway inhibitor (TGF-beta / Smad) Nine species SMAD have been found in protein family, called SMAD1-9,which were all found involved in TGF-BETA signal transduction. They are its receptor downstream signaling molecules, including receptor type, common media type, ...
Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Pirfenidone attenuates chemokine (CC motif