TGF344‐AD rats exhibit cognitive reserve despite continual Aβ and tau accumulationPatient to patient variability in Alzheimer's disease progression complicates treatment efficacy. Furthermore, the presence of Aβ pathology does not always indicate cognitive impairments. Epidemiological evidence of ...
Alzheimer's disease (AD) not only affects cognition and neuropathology, but several other facets capable of negatively impacting quality of life and potentially driving impairments, including altered gut microbiome (GMB) composition and metabolism. Aged (20 + mo) female TgF344-AD and wildtype rats...
TgF344-AD rats exhibited largely intact navigation at 4-5 and 7-8 months of age, with deficits in the hidden platform task emerging at 10-11 months of age. In general, TgF344-AD rats displayed less accurate swim trajectories to the platform and a wider search area around the platform ...
Radiosynthesis was performed using Scintomics GRP automated module via copper-catalyzed18F-fluorination of the chiral boron pinacolate precursor. Brain imaging in wild-type (n = 3) and TgF344-AD rat models (n = 2) at 23 months was performed on microPET Concord R4 scanner. Result [18F]TRACK...
Method Synaptic signaling was assessed in DG and CA1 hippocampal subregions of 9 month old TgF344-AD female rats who underwent long-term (from ages 3 to 9 months) ovarian hormone deprivation. Extracellular dendritic field potential recordings were conducted in the DG by stimulating the media...
Methods USVs were collected from male TgF344-AD (N=19) and wildtype (WT) Fischer-344 rats (N=19) at 6 months (N=38; WT: n=19; TgF344-AD: n=19) and 9 months of age (N=18; WT: n=10; TgF344-AD: n=8) and acoustically analyzed for duration, mean power, principal ...
We observed a decreased power of high theta oscillations in TgF344-AD rats compared to wild-type littermates. Sharp wave-ripple (SWR) analysis revealed an increased SWR power and a decreased duration of SWR during quiet wake in TgF344-AD rats. The alterations in pr...
The present study investigated sex differences in cerebrovascular dysfunction and potential mechanisms in AD using a TgF344-AD rat model. The APP/PS1 TgF344-AD (AD) rats serve as a preferred model to study AD since they recapitulate the complete repertoire of AD-like pathologies in humans. We...
In the prodromal stage of AD, prior to the onset of memory impairments, TgF344-AD rats develop progressive sustained attention deficits. Moreover, a connection between baseline attention deficits and susceptibility to POD-like symptoms following sevoflurane anesthesia was identified. Taken together, ...
Therefore, there is a need for better imaging models which examine vascular responses during the early stages of AD without the confounds of anesthesia. The aim of this study is to develop the methodology for non‐anesthetized 2‐photon fluorescence imaging using the TgF344‐AD rat model to ...