TgF344〢D rats demonstrate deficits in spatial memory and executive function beginning at 6 months which are not exacerbated at 9 or 12 months, but are at 15 months of age. GABAergic and total neuronal counts in the hippocampus and entorhinal cortex of TgF344〢D rats exhibit a similar trend...
Methods USVs were collected from male TgF344-AD (N=19) and wildtype (WT) Fischer-344 rats (N=19) at 6 months (N=38; WT: n=19; TgF344-AD: n=19) and 9 months of age (N=18; WT: n=10; TgF344-AD: n=8) and acoustically analyzed for duration, mean power, principal ...
Sharp wave-ripple (SWR) analysis revealed an increased SWR power and a decreased duration of SWR during quiet wake in TgF344-AD rats. The alterations in properties of SWR and the increased power of fast oscillations are suggestive of neuronal hyperexcitability, as has been demonstrated to occur...
Methods TgF344-AD rats and wild-type littermates were longitudinally evaluated at 3, 6, 9, 12 and 16-18 months of age. Rats underwent [18F]FDG-microPET scans and CSF samplings. CSF glial and immune markers (GFAP, S100B, TREM2, IL-6, TNF-伪, IL-10) were measured ...
Alzheimer's disease (AD) is a global healthcare crisis. The TgF344-AD rat is an AD model exhibiting age-dependent AD pathological hallmarks. We confirmed that AD rats developed cognitive deficits at 6 months without alteration of any other major biophysical parameters. ...
Compared to WT, TgF344-AD rats replicated common findings in AD patients, including decreased N-acetylaspartate in the cortex, hippocampus and thalamus, and decreased glutamate in the thalamus and striatum. Different longitudinal evolution of metabolic concentration was observed between TgF344-AD and ...
RESULTS. There was a significant interaction between age and genotype on sustained attention performance on the 5CSRTT (p=.0070), with TgF344-AD rats displaying more severe age-related attention deficits than littermate controls. Further, working memory was not significantly impacted by age nor ...
In the sucrose preference test, TgF344-AD rats did not show signs of anhedonia but did not increase the volume of liquid consumed when the water was replaced by sucrose solution. These behavioral phenomena were observed at an age when tau accumulation are absent, and where amyloid deposits are...
TgF344-AD rats exhibited largely intact navigation at 4-5 and 7-8 months of age, with deficits in the hidden platform task emerging at 10-11 months of age. In general, TgF344-AD rats displayed less accurate swim trajectories to the platform and a wider search area around the platform ...
Rats were euthanized at 16 months, and brains, retinas, and serum were analyzed for amyloid precursor protein (APP) as a marker of disease progression. Results : TgF344-AD rats exhibited significant cognitive deficits at 15 months of age as measured by Barnes maze (p<0.01), but no changes...