TgF344〢D rats demonstrate deficits in spatial memory and executive function beginning at 6 months which are not exacerbated at 9 or 12 months, but are at 15 months of age. GABAergic and total neuronal counts in the hippocampus and entorhinal cortex of TgF344〢D rats exhibit a similar trend...
Methods USVs were collected from male TgF344-AD (N=19) and wildtype (WT) Fischer-344 rats (N=19) at 6 months (N=38; WT: n=19; TgF344-AD: n=19) and 9 months of age (N=18; WT: n=10; TgF344-AD: n=8) and acoustically analyzed for duration, mean power, principal ...
Sharp wave-ripple (SWR) analysis revealed an increased SWR power and a decreased duration of SWR during quiet wake in TgF344-AD rats. The alterations in properties of SWR and the increased power of fast oscillations are suggestive of neuronal hyperexcitability, as has been demonstrated to occur...
To examine the mechanisms underlying this paradox, TgF344-AD rats were fed a varied high-carbohydrate, high-fat (HCHF) diet to induce obesity from nine months of age representing early stages of AD to twelve months of age in which rats exhibit the full spectrum of AD...
Methods TgF344-AD rats and wild-type littermates were longitudinally evaluated at 3, 6, 9, 12 and 16-18 months of age. Rats underwent [18F]FDG-microPET scans and CSF samplings. CSF glial and immune markers (GFAP, S100B, TREM2, IL-6, TNF-伪, IL-10) were measured ...
Further, working memory was not significantly impacted by age nor across genotypes, suggesting that deficits in sustained attention precede memory impairments in the TgF344-AD rat model of AD. Compared with age-matched wildtype littermates, 18-month-old TgF344-AD rats show significant delays in ...
Thus, we tested the hypothesis that impairments in HD cell stability would be apparent in AD. To test this hypothesis, we used the TgF344〢D rat model of AD which exhibits progressive pathology in cortical﹍imbic regions. Previously, we found that 10 month old TgF344〢D rats make ...
Thus, in cortex, strong couplings of N-acetylaspartate and creatine with myo-inositol in WT, but with taurine in TgF344-AD rats were observed; whereas in the hippocampus, myo-inositol, taurine and choline compounds levels were highly correlated in WT but not in TgF344-AD animals. Further...
TgF344-AD rats exhibited largely intact navigation at 4-5 and 7-8 months of age, with deficits in the hidden platform task emerging at 10-11 months of age. In general, TgF344-AD rats displayed less accurate swim trajectories to the platform and a wider search area around the platform ...
TgF344-AD rats demonstrated significant cognitive impairment in multiple domains, as well as regionally specific GMB dysbiosis. Relationships between peripheral factors were investigated using Canonical Correspondence Analysis (CCA), revealing correlations between GMB changes and both cognitive and metabolic ...