In the current work we aimed to elucidate the role of TGFBR3 in the TGF-β signaling pathway of MFS patients. This was investigated by the quantification of mRNA expression of TGFBR3 and TGFB, as well as a panel of TGF-β signaling-associated target genes in primary dermal fibroblasts of ...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible interstitial lung disease, with no effective cure. Polydatin is a resveratrol glucoside with strong antioxidant, anti-inflammatory and anti-apoptotic properties, which is used for treating health-related disorders such as cardiac...
Cells by Activating the MT2/PI3K/AKT/ETS1 Signaling Pathway Purpose Hyperoxia-induced apoptosis in alveolar epithelial type II cells (AECIIs) plays a critical role in the development of bronchopulmonary dysplasia (B... H Fan,W Qiao-Fang,L Lin,... - 《Lung》 被引量: 0发表: 2023年 ...
Furthermore, it has been suggested that, in general, the growth of tumors is dependent on interactions between multiple inter-dependent cell types [8]. Over the years, advances have been made to gain a better understanding of cell-cell interactions for various cancers and other disease processes...
(IL-15RαSu) fused to an immunoglobulin Fc domain; wherein the second fusion protein further comprises a binding domain that specifically binds to a disease antigen, immune checkpoint molecule or immune signaling molecule, and wherein the IL-15 domain of the first fusion protein binds to the ...
TGF-β signaling in lung health and disease. Int. J. Mol. Sci. 2018, 19, 2460. [Google Scholar] [CrossRef] [PubMed] Wójcik, K.A.; Skoda, M.; Koczurkiewicz, P.; Sanak, M.; Czyż, J.; Michalik, M. Apigenin inhibits TGF-β1 induced fibroblast-to-myofibroblast transition in...
[5]. Particularly, the TGF-β1-SMAD2/3 signaling cascade has been implicated in the advancement of salivary gland fibrosis. For instance, murine models exhibiting submandibular duct ligation displayed significant upregulation of TGF-β1, its receptor, and downstream SMAD transcription factors within ...
Intrauterine adhesion (IUA) is a common gynecological disease with limited therapeutic options. Dulaglutide is a long-acting glucagon-like peptide-1 (GLP-1) analog with some anti-fibrotic and anti-inflammatory properties; however, its action on IUA remai
- happens. Led by researchers at Baylor College of Medicine, the team of scientists found that the Transforming Growth Factor beta (TGF-beta) signaling pathway in uterine cells protects against the disease by suppressing the overgrowth and transformation into cancer cells of the endometrium, the ...
TGF-βs signaling promotes tumorigenesis in glioblastoma, while BMPs suppress tumorigenic potential by inducing tumor cell differentiation. In this review, we discuss the actions of TGF-βs and BMPs on cancer cells as well as in the tumor microenvironment, and their use in potential therapeutic ...