Transforming Growth Factor-β (TFGbeta; TGFβ (TGF-β) is a signaling molecule that mediates signal transduction into cells through binding to a TGFbeta receptor (TGFbetaR; TGFβR (TGF-βR)). TGFbeta signaling activity regulates cell differentiation and growth, the nature of its effect, i....
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible interstitial lung disease, with no effective cure. Polydatin is a resveratrol glucoside with strong antioxidant, anti-inflammatory and anti-apoptotic properties, which is used for treating health-related disorders such as cardiac...
[26]. Recently, inhibition by UA of EMT in cancer cells [84,85] and inhibition of TGF-β signaling in renal epithelial cells [86] were reported. However, relatively few research results refer to the influence of UA on renal disorders, with only a few publications discussing its impact on...
Idiopathic pulmonary fibrosis (IPF) is an irreversible and life-threatening lung disease of unknown etiology presenting only a few treatment options. TGF-β signaling orchestrates a cascade of events driving pulmonary fibrosis (PF). Notably, recent research has affirmed the augmentation of TGF-β rece...
Multiple sclerosis (MS) is a chronic and degenerative disease that impacts central nervous system (CNS) function. One of the major characteristics of the disease is the presence of regions lacking myelin and an oxidative and inflammatory environment. TGF
Although PFD has been widely used to reduce pulmonary fibrosis [21], its effects remain largely unexplored in the renal field. Previous studies reported that PFD is a renoprotective agent that exerts its functions partly by inhibiting the TGF-beta signaling pathway [22,23]. Some studies also ...
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TGF-β signaling leads to opposing effects depending on activin receptor-like kinase-1 (ALK-1) and activin receptor-like kinase-5 (ALK-5) activity, which may lead to either inhibition or stimulation of proliferation, migration, and angiogenesis [22,23] in the same ambiguous way that TGF-β...
Intrauterine adhesion (IUA) is a common gynecological disease with limited therapeutic options. Dulaglutide is a long-acting glucagon-like peptide-1 (GLP-1) analog with some anti-fibrotic and anti-inflammatory properties; however, its action on IUA remains uncertain. The purpose of the experiments ...
The TGF-β family is a representative epithelial–mesenchymal transition (EMT) inducer in both development and disease through SMAD- and non-SMAD-regulated pathways [15,16]. Non-SMAD signaling pathways induce epithelial–mesenchymal transition (EMT) with translation via the PI3K/AKT/mTOR pathway and...