TGF beta signalling in contextJoan Massague
E. Smad-dependent and smad-independent pathways in tgf-β family signalling. Nature 425, 577–584 (2003). 17. Massagué, J. Tgfβ in cancer. Cell 134, 215–230 (2008). 18. Massagué, J. Tgfβ signalling in context. Nature reviews Molecular cell biology 13, 616–630 (2012). 19. ...
In the developing embryo transforming growth factor β (TGFβ) signalling plays a pivotal role in facilitating closure of the embryonic midline11. It is also essential for cell homeostasis in general and is particularly crucial for cardiac and vascular development12,13. Furthermore, defects in TGF...
TGF-[beta]-mediated activation of RhoA signalling is required for efficient [sup.V12]HaRas and [sup.V600E]BRAF transformation Transforming growth factor beta-1 (TGF-beta) acts as both a tumour suppressor and a tumour promoter in a context-dependent manner. The tumour-promoting act... YM Fl...
Molecular basis for antagonism between PDGF and the TGFβ family of signalling pathways by control of miR‐24 expression Top of pageIntroduction Results Discussion Materials and methods Acknowledgements Conflict of Interest References Supporting Information Modulation of the ... MC Chan,AC Hilyard,C Wu...
Figure 16.3.TGF-β signalling. Adapted from Saika S, Ikeda K, Yamanaka O, Sato M, Muragaki Y, Ohnishi Y, et al. Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice. Lab Invest 2004;84:1259–70 and Banh A, Descham...
a number of intratesticular factors are known to influence Leydig cell steroidogenic function [6]. Among these factors, TGF-β1 modulates Leydig cell steroidogenesis [7] and proliferation [8,9]. In this context, Sanderson et al. [10] have demonstrated that, in transgenic mice overexpressingTGF...
Crosstalk between tumour and stromal compartment is based on several signalling pathways. One important cytokine in this context is transforming growth factor beta (TGF-β). The TGF-β superfamily of secreted polypeptides consists of three 25 kDa-proteins (TGF-β1, 2 and 3) and regulates cell ...
Department of Cell Signalling, Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER-CSIC), 41092 Sevilla, Spain 2 Cardiovascular Proteomics, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain 3 CIBER de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid,...
TGF-β regulates both the tumor-forming and migratory abilities of various types of cancer cells. However, it is unclear how the loss of TGF-β signaling components affects these abilities in clear-cell renal cell carcinoma (ccRCC). In this study, we investigated the role of TGFBR3 (TGF-β...