PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF α receptor is negatively regulated by Src family kinases[J] . Marius Vantler,Michael Huntgeburth,Evren Caglayan,Henrik ten Freyhaus,Petra Schnabel,Stephan Rosenkranz.FEBS Letters . 2006 (30)...
are potential binding partners of PDGFR-β (Fig.5c). As expected, the binding of PDGFR-β, talin1 and FAK was stronger with PDGF-BB treatment. Next, we tested whether the PDGFR-β/talin1/FAK complex was activated by PDGF-BB. Western blot assays revealed that phosphorylation of talin1 and...
The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events 文档预览 版权信息 Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works....
domain (PDGF-CChum)66. We could observe that inhibiting PDGFRα signaling by blocking its ligand PDGF-CC indeed preserves BBB integrity, reduces immune cell infiltration and consequently ameliorates EAE. Our data strongly indicate the possibility for establishing a novel treatment specifically targeting ...
Functionally, we found that cells depleted of c-Cbl and Cbl-b were more prone to migrate toward PDGF-BB, whereas no reproducible effect on cell proliferation could be observed. In conclusion, internalization as well as signaling via PDGFRβ are controlled by ubiquitination....
Matuoka K , Shibasaki F , Shibata M and Takenawa T ( 1993 ) Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF . EMBO J , 12 , 3467 – 3473 .Matuoka, K., Shibasaki, F., Shibata, M. and Takenawa, T....
Signaling pathways activated by PDGF-AA, PDGF-BB, HB-EGF, TCM, or VECM.Maren SchwenkeMartin KnöflerPhilipp VelickyCharlotte H. E. WeimarMichelle KruseAnnemarie SamalecosAnja WolfNick S. MacklonAnaMaria BambergerBirgit Gellersen
Memo KO MEFs have defects in cell-autonomous S1PR signaling induced by PDGF.Shunya KondoAlessia BottosJeremy C. AllegoodRegis MassonFrancisca G. MaurerChristel GenoudPatrick KaeserAndrea HuwilerMasato MurakamiSarah Spiegel
Activation of relevant downstream signaling pathways was assessed by immunofluorescence in confocal microscopy and by Western blot analysis. Functional outcomes were confirmed with bulk and single cell proliferation assays and motility measurements. In non-confluent (sparse) cultures PDGF-BB stimulation ...
JNK signaling activated by Platelet-Derived Growth Factor D (PDGF-D)stimulates secretion of Vascular Endothelial Growth Factor-C (VEGF-C)by cancer-associated fibroblasts to promote lymphangiogenesis and early. Fabris M. Digestive and Liver Disease . 2015...