TGFbeta signalling
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[2] Vander Ark, A., Cao, J., & Li, X.. TGF-β receptors: In and beyond TGF-β signaling [J]. Cellular Signalling. 2018, 52, 112–120.
2. Lewis KA, et al. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature. 2000;404(6776):411-414.3. Heldin CH, Moustakas A. Signaling Receptors for TGF-β Family Members. Cold Spring Harb Perspect Biol. 2016;8(8):a022053. Published 2016 Aug 1.4...
Signalling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, whichcatalysesthephosphorylationof the Type I receptor. Each class of ligand binds to a specific type II receptor[2].In mammals ...
TGF-beta signalling prevents pancreatic beta cell death after proliferationObjectivesMaintenance of functional beta cell massMaoNingxia... Mao,Yuanyuan,Lu,... - 《Cell Proliferation》 被引量: 8发表: 2015年 TGF-beta signalling prevents pancreatic beta cell death after proliferation TGF-β signalling ...
Mice with targeted disruptions of the transforming growth factor-β1 ( TGF-β1) gene or TGF-β1 intracellular signalling pathways develop intestinal inflam... G Monteleone,F Pallone,TT Macdonald - 《Trends in Immunology》 被引量: 647发表: 2004年 TGF-|[beta]|1 and Smad7 in the regulation...
The intracellular mechanism of transforming growth factor-beta (TGFbeta) signalling via kinase receptors and SMAD effectors is firmly established, but recent studies of human cardiovascular syndromes such as Marfan syndrome and pre-eclampsia have refocused attention on the importance of regulating the ava...
Betasuperfamilyofligandsinclude:Bonemorphogeneticproteins(BMPs),Growthanddifferentiationfactors(GDFs),Anti-müllerianhormone(AMH),Activin,NodalandTGFβ's[1].SignallingbeginswiththebindingofaTGFbetasuperfamilyligandtoaTGFbetatypeIIreceptor.ThetypeIIreceptorisaserine/threoninereceptorkinase,whichcatalysesthe...