We conducted a cross-sectional study investigating community-dwelling older population to determine association between immunoscenescence marker, inflammatory cytokines and frailty. Frailty status was classified with 33-item modified frailty index and latent class analysis was applied to explore the latent ...
Combining these two cellular markers might constitute a more robust biomarker for pre-frail or frail diagnosis than using a single marker. Additionally, an association between the Tfh2/Tfh17 cell ratio and frailty was only found in females, which suggests that detecting frailty based on markers ...
5、gMolecule-CXC Chemokine Receptor 5(CXCR5)Hallmark TFH cell surface markerReceptor for chemokine CXCL13Work when CCR7 expression is lowT cell positioning to follicular GCActivin A plays critical role in regulation Moser B. CXCR5, the Defining Marker for Follicular B Helper T (TFH) Cells.J. ...
1. Mosmann, T.R., et al., (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2. Chen Y., et al., (1994) Regulatory T cell clones induced by oral tolerance:suppression of autoimmune ...
Recently, another T cell subset sharing many common features with Tfh cells has been identified in several autoimmune diseases. These CXCR5−CD4+ICOS+CD40L+T cells named T peripheral helper (Tph) cell are also able to help B cells and have been observed in inflamed tissue in autoimmune diseas...
上文中,所述滤泡辅助性t细胞可为hbv表面抗原特异性滤泡辅助性t细胞;所述抑制调节性t细胞活性或清除调节性t细胞的物质可为抑制ctla4活性的物质或白喉毒素。所述抑制ctla4活性的物质可为ctla4抗体。所述ctla4抗体具体可为bioxcell产品,所述白喉毒素具体可为sigma-aldrich产品。
antigenmarker.AdopttheImmunomagneticbeadssortingmethodtoseparatetheCXCR5+cells.TestthecellpurityandcompositionoftheCXCR5+cellsbyflowcytometry.4.Mixedcultivation:PuttheCXCR5十cellsandhumanlivercelllinesHepG2.2.15cellsinvitromixedcultivating1week.5・ Flowcytometricdetection:AftertheCXCR5+cellsandhumanlivercell1i11es...
6c); but low levels of the signature marker of “ex-T-bet” Tfh cell, NKG2D, compared with “ex-T-bet” Tfh cells published by Fang et al. (Supplementary Fig. 6d)17. These data suggest that Th1-like Tfh cells observed in ZIKV infection are not the “ex-T-bet” Tfh cells ...
大家好,本周向大家分享的文献的是2022年1月发表在Immunity杂志上的题为“TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures” 的一篇文章。此文阐明了TGF-β介导了SATB1(special AT-rich sequence-binding protein-1...
Nodal peripheral T-cell lymphomas and, in particular, their lymphoepithelioid (Lennert's) variant are often derived from CD8(+) cytotoxic T-cells Virchows Arch, 445 (2004), pp. 334-343 Google Scholar 7 P Went, C Agostinelli, A Gallamini, et al. Marker expression in peripheral T-cell lymp...