A: GESA analysis revealed that MACC1 was enriched in glycolytic signaling pathways; B: The correlation between MACC1 and glycolytic marker genes; C: Detect the cell viability of rectal cancer oxaliplatin resistant cells ...
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在再喂养条件下,肝脏Tcf7l2缺乏显著上调了Srebf1c mRNA水平(图第7a段)。然而,TCF7L2不影响胰岛素、SREBP1c(自动调节)或LXR激动剂T0901317诱导的Srebf1c启动子活性(图7b)。因此,我们研究了TCF7L2是否调节可以在肝脏脂肪变性发...
Nuclear CTNNB1 interacts with a variety of proteins; the best characterized are the T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors. This family contains four members, each of which recognize and bind to a shared DNA motif (“Wnt-responsive elements,” or WREs) through...
Transcription factor 7-like 2 (TCF7L2, also known as transcription factor 4 [TCF4]) belongs to the T cell-specific highmobility group box-containing family of transcription factors that mediates the canonical Wnt signalling pathway [1, 2]...
A polymorphism in the transcription factor 7-like 2 (TCF7L2) gene has been found to be associated with type 2 diabetes in case-control studies. We aimed to estimate associations of the marker rs7903146 (C/T) polymorphism with fasting glucose, lipids, dia
Interestingly, in control individuals, there was weak evidence of association of the T at-risk allele with reduced fasting insulin levels and insulin secretion index (homeostasis model assessment of 尾-cell function) in control individuals. We conclude that the TCF7L2 T at-risk allele variation ...
The TCF7L2 rs7903146 T-allele shows the strongest association with type 2 diabetes (T2D) among common gene variants. The aim of this study was to assess circulating levels of metabolites following a meal test in individuals carrying the high risk rs79034
We assessed promoter activity of the intergenic region in both orientations in cancer cell lines derived from breast (AU565, SKBR3), colon (HCT-15, KM12), and stomach (AGS) cancers, as well as in embryonic human kidney (HEK293T) cells. The intergenic segment was active in both orientati...
The leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) is considered to be a stem cell marker in many normal tissues and promotes tissue development, regeneration, and repair. LGR6 is also related to the initiation and progression of some