Table 4. Multinomial logistic regression analyses of significant T-cell marker of Prefrailty and Frailty from stepwise forward selection Prefrailty Frailty OR 95% CI P-value OR 95% CI P-value Male sex 1.01 0.67 − 1.55 Age, years 1.01 0.98 − 1.04 Number of comorbidity 1.21 1.06 − ...
Earlier studies conducted on HIV-infected patients suggested that PD-1 is a marker of early T-cell exhaustion representing a stage of impaired proliferation but still relatively well preserved function manifested in the ability of cytokine synthesis64, whereas Tim-3 is a marker of more advanced T-...
摘要: The chromosomes from 2 cases of lymphoma involving proliferation of abnormal T-lymphocytes are described. The tumours differed histologically and chromosomally, although certain of the structural chromosome changes found are of common occurrence in other, mostly B-cell, lymphomata....
Enzymatic A-chain activity was measured by the capacity of the toxin subunit to inhibit protein synthesis in a cell-free system.13 Antibody binding was assessed by fluorescence-activated cell sorter (FACS IV, Becton Dickinson, Mountain View, Calif) analysis on the target cells.6 Cytotoxicity was...
流式细胞仪（flow cytometer）是一种能够探测和计数以单细胞液体流形式穿过激光束的细胞检测装置，由于在检测中使用的细胞标志示踪物质为荧光标记物，因此，用来分离、鉴定细胞的流式细胞仪有被称为荧光激活细胞分类仪（fluorescence activated cell sorter,FACS）,是分离和鉴定细胞群及亚群的一种强而有力的应用工具。其...
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To evaluate the dependency of tumor organoid-reactive T cell responses on IFNγ, we compared T cell expression of the activation marker CD137 upon stimulation with tumor organoids that were either pre-stimulated with IFNγ or left untreated (Figure 4A). For 4 of 5 cases tested, similar CD8...
Furthermore, the depletion of Treg cells in mdx mice will indirectly lead to a significant increase in the expression of PD-L1 on pro-inflammatory and anti-inflammatory macrophages and a significant decrease in the expression of anti-inflammatory -activated marker CD206, but will exercise no ...
b, Heat map showing the expression of the top five marker genes for each significant cell cluster identified by Seurat. The cell identity assigned to each cluster is indicated on the bottom of each column. c, t-SNE plots of all 14,685 single-cell transcriptomes analysed by the 10x Genomics...
In addition to potent antibody responses, SOSIP/3M-052 immunizations induced modest CD4+T cell responses (Extended Data Fig.2a). There was no CD8+T cell response, as seen previously22. Of note, HVV immunizations did not impact CD4+T cell responses to Env immunization. Furthermore, there ...