Traditional functional assays for studying antigen-specific CD4+ T cells, such as proliferation or cytokine secretion, are not truly antigen-specific. The direct detection of antigen-specific CD4+ T cells has been difficult, due to the low frequency of these T cells (down to 1 in 100,000 whi...
经流式细胞水平验证,ACROBiosystems 自主开发的HLA-A*02:01&B2M&NY-ESO-1Tetramer产品,可很好的与TCR结合,且活性明显高于竞品 2e5 of NY-ESO-1 TCR-HEK293 cells (pool) were stained with PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) tetramer Pr...
经流式细胞水平验证,ACROBiosystems 自主开发的HLA-A*02:01&B2M&NY-ESO-1 Tetramer产品,可很好的与TCR结合,且活性明显高于竞品 2e5 of NY-ESO-1 TCR-HEK293 cells (pool) were stained with PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) tetramer Protein(Fig B)and negative control prot...
MHC tetramers are used for the detection and monitoring of antigen-specific T cells to study the adaptive immune response, including T cell development, disease progression, and evaluation of therapeutics, vaccinations, and other interventions that may have an impact on cellular immune responses. In...
2e5 of NY-ESO-1 TCR-HEK293 cells (pool) were stained with PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) tetramer Protein(Fig B)and negative control protein respectively (Fig. A), and competitor-M represented competitor protein (Fig. C). PE signal was used to evaluate the...
Nur, H. et al. (2013). “Preclinical Evaluation of Invariant Natural Killer T Cells in the 5T33 Multiple Myeloma Model” PLoS ONE 2013 8(5): e65075. Figure 4.来自幼稚和 5T33MM 小鼠的血液、BM、脾脏和肝脏的鼠 iNKT 细胞的代表性 FACS 分析。 活细胞(7-AAD 阴性)用 a-GalCer/CD1d 四聚体...
检测技术是在单细胞水平上标记目标T细胞,并通过流式细胞术对细胞进行分析,从而成为一种快速、简便的检测抗原特异性T细胞(antigen-specificT cells)的定性及定量分析方法。 MHC分子在免疫应答过程中发挥着抗原识别的作用,主要功能是将抗原呈递给T细胞,以区分自身(我们的细胞和组织)和非己(入侵者或修饰的自身)。以人类为...
This protein exists in cells as tetramers. 20.研究人员正在探索用tetramer四聚体作为药物传递的载体。 Researchers are exploring the use of tetramers as carriers for drug delivery. 21.这个疾病与tetramer四聚体的异常形成有关。 This disease is associated with abnormal formation of tetramers.©...
Reagent for direct detection of antigen-specific T cells. MHC tetramer technology is based on the ability of MHC-peptide complexes to recognize the antigen-specific T cells at a single cell level.
MAIT cellsMR1-restricted T cellsT cell cloningTetramers are a powerful tool for identification of T cell subsets that are restricted by specific antigen presenting molecules and their cognate antigens. The generation of T cell clones from......