8 A second signal is required for class switching Receptors for IgE There are 2 known receptors for IgE, FcεRI and CD23 (FcεRII). FcεRI, the high-affinity receptor for IgE, is composed of a tetramer, αβγ2, on mast cells and basophils and as a trimer, αγ2, on other...
Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers A major group of natural killer (NK) T cells express an invariant Vα14+T cell receptor (TCR) specific for the lipoglycan α-galactosylceramide (α-GalCer)... JL Matsuda,OV Naidenko,L Gapin,.....
This, and structurally related lipids, potently activate CD1d-restricted natural killer T (NKT) cells that express the semi-invariant Vα14-Jα18 T-cell receptor (TCR) in mice (and the Vα24-Jα18+ equivalent cells in humans)101. α-GALCER-LOADED CD1D TETRAMERS A complex of four CD1d ...
Perspectives on Immunotherapy in Prostate Cancer and Solid Tumors: Where Is the Future? The goals of any cancer therapy are to improve disease control, palliate pain and improve overall survival. We are fortunate to have in our cancer armament... A Snyder,JE Tepper,SF Slovin - 《Seminars in...
Hyperexpression of classical HLA class I (HLA-I) molecules in insulin-containing islets has become a widely accepted hallmark of type 1 diabetes pathology. In comparison, relatively little is known about the expression, function and role of non-classical subtypes of HLA-I. This review focuses on...
(2002) Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer Gastroenterology 123 1031–43 12360465 10.1053/gast.2002.36020 1:CAS:528:DC%2BD38Xotl2gurw%3D Article PubMed CAS Google Scholar K Tsuneyama M Yasoshima K Harada K Hi...
These tetrameric (oligomeric) receptor complexes can transduce signals to the canonical, Smad-dependent, signaling pathway and the non-canonical, Smad-independent pathway (p38-MAPK) [32]. Of the 14 BMPs, only BMP-2, -4, -5, -6, -7, and -9 have a high osteogenic activity [33,34]....
is still missing. One of the most important events in the HCV assembly is the nucleocapsid formation which is driven by the core protein, that can oligomerize upon interaction with viral RNA, and is orchestrated by viral and host proteins. Despite a growing number of new factors involved in ...
The protein MASP-1 can form a tetrameric complex with MASP-2 similar to that formed by the subunits C1r and C1s; specifically, MASP-2 cleaves C4 and C2. The events resulting from this reaction are identical to those occurring in the classical pathway [24] (Figure 1). 2.1.3. Alternative...
The second group, to which the BKCa channel belongs, is a tetramer of subunits with 7 transmembrane segments and a P-loop (7TM/1P). A third group, which includes leak channels, possesses 4 transmembrane segments and two pore-forming domains (4TM/2P). Unlike the other groups that form ...