Although IAAL increased the proportion of terminal-CD8(+) T cells relative to the pre-culture proportions, patients with a high CD57-FOXP3(+) CD8(+) T cell percentage exhibited repressed terminal-CD8(+) T cell induction, leading to poor patient prognosis. Terminally differentiated CD27-CD8(...
Terminally Differentiated CD8~+ T Cells Negatively Affect Bone Regeneration in HumansThere is growing evidencehatdaptive immunityontributeso endogenousegeneration... - 《Science Translational Medicine》 被引量: 0发表: 2013年 Erratum: Terminally differentiated CD8+ T cells negatively affect bone regeneratio...
T lymphocytes were isolated from 35 patients with stage IV gastric carcinomas (17 men and 18 women; aged 41-84 years) receiving immunotherapy using AALs (IAAL). Using fluorescence activated cell sorting, CD8, CD27, CD57, and forkhead box protein 3 (FOXP3) expression was investigated on ...
Altered proportions of naive, central memory and terminally differentiated central memory subsets among CD4+ and CD8 + T cells expressing CD26 in patients with type 1 diabetes. J Clin Immunol. 2011; 31 :977–84.MATTEUCCI E;GHIMENTI M;DI B S;.Altered proportions of naive,central memory and ...
5a–c), that the LN NKG2a/clowCD16+ NK cells expressed high levels of markers known to be associated with NK cell terminal differentiation. Also, the NKG2a/chighCD16− NK cells showed again the less differentiated profile and expressed high levels of transcripts coding for NKG2D (KLRK1),...
Terminal T cell exhaustion is characterized by metabolic reprogramming To analyze the transcriptional-metabolic programs along the developmental trajectories of exhausted T cells, we performed single-cell (sc) RNA sequencing of CD44+PD-1hiCD8+T cells isolated from chronically infected wild-type (WT) ...
This CD39high CD8+ T cell population is enriched for cells with the phenotypic and functional profile of terminal exhaustion. These findings provide a new marker of T cell exhaustion, and implicate the purinergic pathway in the regulation of T cell exhaustion. 展开 ...
E+CD4+T-cells (Fig.1g, representative gating strategy in Supplementary Fig.1b); however, it did not impact the frequency of NKG2a/c+CD8+T-cells (Fig.1h, representative gating strategy in Supplementary Fig.1c) nor did it enhance T-cell responses whether by T-bet expression, which ...
37 This model identified IFN-γ secretion predominantly from CD56pos cells during peripheral blood mononuclear cell (PBMC)/Pf-iRBC coculture experiments.37 Cytotoxic CD56dimCD16pos NK/NK T cells and CD8pos T cells are protective against malaria38; however, EBV or CMV coinfections were not ...
Using highly multiplexed peptide-MHC tetramer staining of unexpanded cells from blood, liver, and tumor tissues from 46 HCC patients, we detected 91 different antigen-specific CD8+ T cell populations targeting HBV, neoantigen, tumor-associated, and disease-unrelated antigens. Parallel high-dimensional...