[8] Buratti E. Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved from https://alsnewstoday.com/news/als...
Thus, these findings support the concept that FTLD and ALS represent a clinicopathologic spectrum of one disease, that is, TDP-43 proteinopathy.doi:10.1159/000109758Linda K. KwongCenter for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, andKunihiro Uryu...
11.Ihara, R., et al., RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy. Human molecular genetics, 2013. 22(22): p. 4474-4484. 12.Mollasalehi, N., et al., An allos...
Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved from alsnewstoday.com/news/a [10] ALS News Today. (...
Emerging Therapies and Novel Targets for TDP-43 Proteinopathy in ALS/FTD. PMID: 35790708 Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis. PMID: 30837838 佰乐博生物作为法国AntibodySystem和ProteoGenix在亚洲的独家总代理,提供近30,000种生命科学试剂,核心产品涵盖蛋白...
we find that the in vivo delivery of an ataxin-2-targeting Cas13 system to a mouse model of TDP-43 proteinopathy improved functional deficits, extended survival, and reduced the severity of neuropathological hallmarks. Further, we benchmark RNA-targeting CRISPR platforms against ataxin-2 and...
文章在《中国神经再生研究(英文版)》杂志2022年7 月7 期发表。 Keszycki R, Jamshidi P, Kawles A, Minogue G, Flanagan ME, Zaccard CR, Mesulam MM, Gefen T, Geula C (2022) Propagation of TDP-43 proteinopathy in neurodegenerative disorders. Neural Regen Res 17(7):1498-1500....
8 ✉Aberrant aggregation of the RNA-binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by haploinsuf f i ciency in the gene encoding progranulin 1,2 . However, the mechanism leading to TDP-43 proteinopathy remains unclear. Here we use single-...
TDP-43 Proteinopathy Specific Biomarker Development. PMID: 36831264 Emerging Therapies and Novel Targets for TDP-43 Proteinopathy in ALS/FTD. PMID: 35790708 Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis. PMID: 30837838 ...
Excessive TDP-43 accumulation is a pathological hallmark of ALS and is associated with Parkin protein reduction in spinal cord neurons from sporadic ALS patients. In this study, we reveal that Parkin and PINK1 are differentially misregulated in TDP-43 proteinopathy at RNA and protein levels. ...