[8] Buratti E. Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved fromhttps://alsnewstoday.com/news/als-...
[8] Buratti E. Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved from https://alsnewstoday.com/news/als...
Genetic mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Importantly, TDP-43 proteinopathy, characterized by aberrant phosphorylation, ubiquitination, cleavage or nuclear depletion of TDP-43 in neurons and glial cells, is ...
11.Ihara, R., et al., RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy. Human molecular genetics, 2013. 22(22): p. 4474-4484. 12.Mollasalehi, N., et al., An allos...
[8] Buratti E. Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved fromhttps://alsnewstoday.com/news/als...
[8] Buratti E. Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved fromhttps://alsnewstoday.com/news/als...
具有TDP-43 病理学的 FTLD的英文名字是FTLD with TDP-43 pathology。基因解码表明:具有TDP-43病理学的前额颞叶退化症(Frontotemporal Lobar Degeneration,FTLD)在中文中也被称为额颞叶退化症、额颞叶变性症等。在英文中,具有TDP-43病理学的FTLD也被称为TDP-43 proteinopathy。
TDP-43 Proteinopathy Specific Biomarker Development. PMID: 36831264 Emerging Therapies and Novel Targets for TDP-43 Proteinopathy in ALS/FTD. PMID: 35790708 Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis. PMID: 30837838 ...
This review explores the causes of TDP-43 aggregation, FTLD/ALS-related genes, key autophagy factors, and autophagy-based therapeutic strategies targeting TDP-43 proteinopathy. Understanding the underlying pathological mechanisms of TDP-43 proteinopathy can facilitate therapeutic interventions....
文章在《中国神经再生研究(英文版)》杂志2022年7 月7 期发表。 Keszycki R, Jamshidi P, Kawles A, Minogue G, Flanagan ME, Zaccard CR, Mesulam MM, Gefen T, Geula C (2022) Propagation of TDP-43 proteinopathy in neurodegenerative disorders. Neural Regen Res 17(7):1498-1500....