深入研究发现，afami-cel浸润肿瘤以及启动获得型免疫响应受干扰素gamma驱动。另外，afami-cel的收入-风险比率（benefit–risk profile）也是可以接受的，也就是对疗法响应及时，时程也算久，滑膜肉瘤患者疗效尤为显著。当然，I期临床试验样本数较少，并不足以得出明确结论。综上所述，这个I期临床试验，检测了afami-ce...
MAGE-4一般表达于实体瘤中,包括滑膜肉瘤(synovial sarcoma,简称SS)、黏液型脂肪肉瘤(myxoid/round cell liposarcoma,简称MRCLS)、非小细胞肺部肿瘤(non-small-cell lung cancer,简称NSCLC)、头颈鳞状细胞肿瘤(head and neck squamous cell carcinoma,简称HNSCC)、卵巢(ovarian)癌、尿道上皮细胞(urothelial)肿瘤、黑色素...
TCR gene recombination and alpha beta-gamma delta lineage divergence: productive TCR-beta rearrangement is neither exclusive nor preclusive of gamma delta cell development. J Immunol. 1996;157(10):4293-6. [5] Davis, M. M. & Chien, Y. H. in Fundamental Immunology (ed. Paul, W. E.) ...
[关键词] 白血病 ,粒细胞 ,急性 ;聚合酶链反应 ;基因重排 ,γ链 T 细胞抗原受体 [中图分类号] R733 .71 [文献标识码] A [文章编号] 1001‐4047(2002)03‐0211‐03 A STUDY ON T CELL RECEPTOR GAMMA GENE REARRANGEMENT IN ACUTE MYELOID LEUKEMIA L EI Ke ,L U Jie , GU Renkai ,et al Instit...
[4] Burtrum DB, Kim S, Dudley EC, Hayday AC, Petrie HT. TCR gene recombination and alpha beta-gamma delta lineage divergence: productive TCR-beta rearrangement is neither exclusive nor preclusive of gamma delta cell development. J Immunol. 1996;157(10):4293-6. ...
[4] Burtrum DB, Kim S, Dudley EC, Hayday AC, Petrie HT. TCR gene recombination and alpha beta-gamma delta lineage divergence: productive TCR-beta rearrangement is neither exclusive nor preclusive of gamma delta cell development. J Immunol. 1996;157(10):4293-6. ...
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[4] Burtrum DB, Kim S, Dudley EC, Hayday AC, Petrie HT. TCR gene recombination and alpha beta-gamma delta lineage divergence: productive TCR-beta rearrangement is neither exclusive nor preclusive of gamma delta cell development. J Immunol. 1996;157(10):4293-6. ...
IgH, TCR-gamma, and TCR-beta gene rearrangement in 80 B- and T-cell non-Hodgkin’s lymphomas: study of the association between proliferation and the so-called "aberrant" patterns. García M J,Martínez-Delgado B,Granizo J J,Benítez J,Rivas C. Diagnostic molecular path...
T细胞受体工程T细胞(engineered T cell receptor-T cell,TCR-T)疗法和嵌合抗原受体T细胞(chimeric antigens receptor-T cell,CAR-T)疗法是将T细胞特异性重定向到肿瘤抗原的两种主要方法[1],作为最新、最有效的两种免疫治疗技术,近年来受到了广泛关注。在临床试验中,...