Four specimens from the 12 prediagnostic for cutaneous T-cell lymphomas showed presence of T-cell clones, identical to subsequent clones detected when lymphoma was fully established. In specimens where histology is not diagnostic and T-cell receptor-gamma gene analysis is positive, patients should ...
T cell receptor gene therapy: strategies for optimizing transgenic TCR pairing T cell receptor (TCR) gene therapy provides patients with autologous T cells that are genetically engineered with TCRαβ chains and constitutes a promising approach for the treatment of tumors and virus infections. Among ...
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes ...
H. et al. Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region. Blood 102, 3530–3540 (2003). Article CAS PubMed Google Scholar Van Dongen, J....
Gamma delta T cell receptor-positive cells of the human gastrointestinal mucosa: occurrence and V region gene expression in Heliobacter pylori-associated gastritis, coeliac disease and inflammatory bowel disease. Clin Exp Immunol 1991;84:440-4....
T-cells are a subset of lymphocytes that play a large role in the immune response. The TCR (T-cell receptor) is a complex of integral membrane proteins that participate in the activation of T-cells in response to an antigen. Stimulation of TCR is triggered ...
T cell receptor (TCR) signaling regulates important developmental transitions, partly through induction of the E protein antagonist, Id3. Although normal γδ T cell development depends on Id3, Id3 deficiency produces different phenotypes in distinct γ
Unconventional T cells T cell receptor Ligand recognition Innate immunity Adaptive immunity Stress immune surveillance Infection Cancer Immunotherapy 1. Introduction: how does it feel, like a complete unknown? The past three decades have witnessed remarkable progress in our understanding of antigen presentat...
[Abstract]Engineered T cell receptor-T cell (TCR-T) therapy and chimeric antigen receptor-T cell (CAR-T) therapy are currently the two most effective ways of adoptive T cell therapy. Because CAR can only recognize antigens on the surface of t...
在小鼠 DN2 或 DN3 细胞发育阶段,Tcrd,Tcrg 和 Tcrb 等 T 细 胞受体(T cell receptor,TCR)基因开始重排,根据 TCR 基因类型,表达 γδTCR 的细胞发育为 γδT 细胞[7-8]。重排成功的 TCRβ 链与 pre-Tα 链组成 pre[1]TCR,pre-TCR ...