Clonal T-cell receptor-gamma2 gene rearrangement was positive. A diagnosis of extranodal NK/T-cell lymphoma, nasal type, was made. This is a rare case, with slow course and survival for >51 months with the presentation only occurring in the skin....
Gamma delta T cell receptor-positive cells of the human gastrointestinal mucosa: occurrence and V region gene expression in Heliobacter pylori-associated gastritis, coeliac disease and inflammatory bowel disease. Clin Exp Immunol 1991;84:440-4....
Molecular genetic analysis for rearrangement of the T-cell receptor gamma gene was performed in reference laboratories on original material using the polymerase chain reaction- (PCR-) denaturing gradient gel electrophoresis (20 patients) and the PCR-single-strand conformation polymorphism techniques (patien...
Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature 375, 795–798 (1995). Article CAS PubMed ADS Google Scholar Hogquist, K. A., Gavin, M. A. & Bevan, M. J. Positive selection of CD8+ T cells induced by major ...
TCR, T cell receptor; EBV, Epstein-Barr virus genome (using nested PCR and (only for cases no. 7 and 8) EBER RISH): −, absent; +/−, slight; +, moderate; ++, intense; PTL s/m–m/l, pleomorphic small/medium–medium/large size; IB, immunoblastic; BT, blastic transformation;...
Hepatosplenic T-cell lymphoma: sinusal/sinusoidal localization of malignant cells expressing the T-cell receptor gamma delta Blood (1990) L. Lay et al. Validation and interpretation of IGH and TCR clonality testing by Ion Torrent S5 NGS for diagnosis and disease monitoring in B and T cell canc...
The tissue was found to be positive for the T-cell receptor (TCR) by gamma gene rearrangement studies by PCR analysis (Figure 5). Immunoglobulin heavy chain rearrangement (IgH) by PCR analysis did not detect a clonal B-cell population, thereby confirming T-cell lymphoma. A bone marrow ...
Our laboratories previously reported that the proportion of lymphocytes bearing the gamma/delta T-cell receptor (TcR) is twofold greater in human milk lymphocyte suspensions than in autologous and heterologous blood samples. The present investigation shows that gamma/delta colostral T cells preferentially...
Hrd1 gene deletion impairs T-cell activation is unlikely due to the altered expression levels of cell surface receptors, because the expression of TCR complex including TCRb and CD3e and the co-stimulatory receptor CD28 are indistinguishable between WT and Hrd1-null T cells from the spleen and...
Significantly increased T-cell infiltration, T-cell receptor (TCR) repertoire diversity, effector gene expression, activation status, and exhaustion marker expression were observed in both α9 and α7 HPV-positive CC as compared to HPV-negative CC. These observations provide strong evidence that the...