Expanded TCR Vbeta subsets of CD8(ϩ) T-cells in late-onset myasthenia gravis: novel par- allels with thymoma patients. J Neuroimmunol 2009;216:85-91.B. Tackenberg,K. Schlegel,M. Happel,C. Eienbröker,K. Gellert,W.H. Oertel,A. Meager,N. Willcox,N. Sommer.Expanded TCR Vβ ...
These findings point out the fact that thymocytes in SCID-bg mice have a peculiar characteristic compared to CB-17-scid mice, and provide evidence of TCR beta-independent development of thymocytes to the DP stage. 展开 关键词: CD4 CD8 mice scid thymocyte ...
展开 关键词: Animals Oncorhynchus mykiss Humans T-Lymphocyte Subsets CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Fish Diseases Receptors, Antigen, T-Cell, alpha-beta Immunophenotyping DOI: 10.1371/journal.pone.0060175 被引量: 21 年份: 2013 收藏...
Structure and diversity of the T cell antigen receptor beta-chain in a teleost fish J. Immunol., 155 (1996), pp. 699-706 Google Scholar Somamoto et al., 2000 T. Somamoto, T. Nakanishi, N. Okamoto Specific cell-mediated cytotoxicity against a virus-infected syngeneic cell line in ginbun...
Shinya Tanaka1,3, Kenji Chamoto1,Yuki Kagoya1, Kayoko Saso1, Tingxi Guo1,2, Mark Anczurowski1,2, Marcus O. Butler1,4 & Naoto Hirano1,2 Recent high throughput sequencing analysis has revealed that the TCRβ repertoire is largely different between CD8+ and CD4+ T cel...
The epithelium of the mouse small intestine harbors an abundant CD8αα+TCRαβ+ intraepithelial lymphocyte (IEL) population. This unique I
1). CD8+ T cells from PDCD1−/− P14 TCR-transgenic mice re-expressing PD-1 or vehicle spread on gp33:H2-Db (but not BSA) surface (Fig. 1a–c), indicating that the antigen recognition machinery alone is able to support spreading without adhesion molecules (e.g. integrins) used ...
We have previously shown that depletion of TCR-V beta 8+ T cells by treatment with mAb reduces the curative effectiveness of low dose melphalan (L-phenylalanine mustard; L-PAM) for mice bearing a large MOPC-315 tumor and extensive metastases. Here we show that V beta 8+/CD8+ T cell lin...
展开 关键词: Humans CD8-Positive T-Lymphocytes Cells, Cultured Receptors, Antigen, T-Cell, alpha-beta Polymerase Chain Reaction Sequence Analysis, DNA Sequence Analysis, Protein Transcription Initiation Site Gene Expression Adult DOI: 10.1371/journal.pone.0040386 被引量: 31 年份...
新抗原和病毒肽由主要组织相容性复合体 I(MHC-I)呈递,它通过被携带 CD8 抗原(CD8+)的 T 细胞表面的 T 细胞受体识别而引发免疫反应。免疫原性肽或克隆扩增的反应性 T 细胞的鉴定为开发新疫苗、诊断方法和免疫疗法提供了很好的机会。 因此,学界已经开发了许多实验方法,例如四聚体分析、四聚体相关 T 细胞受体测...