2022年4月20日,由香雪生命科学研发的一款创新型TCR-T产品——“TAEST1901注射液”,获中国国家药监局(NMPA)的临床试验许可,拟用于治疗晚期肝癌或其它晚期肿瘤(HLA-A*02:01、肿瘤抗原AFP表达阳性)。 3 CRTE7A2-01 ▲图源“NMPA官网” ...
随着科研人员的不懈努力，在免疫靶标的选择、TCR-T的转染优化等方面不断取得进展，相信TCR-T疗法必将在肿瘤领域发挥重要作用，为更多患者带来治疗的新希望。参考资料：[1]D'Angelo SP, Araujo DM, Abdul Razak AR, et al. Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell ...
随着科研人员的不懈努力,在免疫靶标的选择、TCR-T的转染优化等方面不断取得进展,相信TCR-T疗法必将在肿瘤领域发挥重要作用,为更多患者带来治疗的新希望。 参考资料: [1]D'Angelo SP, Araujo DM, Abdul Razak AR, et al. Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarco...
2024年3月27日,Adaptimmune公司联合纪念斯隆-凯特琳癌症中心、华盛顿大学医学院、德州大学MD安德森癌症中心等多家机构的研究人员,在《柳叶刀》发表了题为:Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPE...
随着科研人员的不懈努力,在免疫靶标的选择、TCR-T的转染优化等方面不断取得进展,相信TCR-T疗法必将在肿瘤领域发挥重要作用,为更多患者带来治疗的新希望。 参考资料: [1]D'Angelo SP, Araujo DM, Abdul Razak AR, et al. Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarco...
[5] Luo W, Ma L, Wen Q, Wang N, Zhou MQ, Wang XN. Analysis of the interindividual conservation of T cell receptor alpha- and beta-chain variable regions gene in the peripheral blood of patients with systemic lupus erythematosus. Clin Exp Immunol. 2008 Dec;154(3):316-24. doi: 10.1111...
最让人期待的莫过于即将上市的Afami-cel了。1月31日，Adaptimmune Therapeutics公司宣布，美国食品药品监督管理局（FDA）已经接受了其工程化T细胞受体（TCR）T细胞疗法afamitresgene autoleucel（Afami-cel）的生物制剂许可申请（BLA），并授予其优先审评资格。该申请的目标日期为2024年8月4日。在SPEARHEAD-1试验中，...
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, wh
Description: This RR3-15 monoclonal antibody reacts with the mouse T-cell receptor (TCR) V beta 11 chain. Composed of an alpha and beta chain, TCR specificity is typically determined by Va, Ja, Vb, Db, and Jb gene rearrangement. The RR3-15 antibody recognizes the V beta 11 chain on ...
T cell receptor (TCR)-beta gene recombination: dissociation from cell cycle regulation and developmental progression during T cell ontogeny. J Exp Med. 1997; 185 :1549–1556.Tourigny MR, Mazel S, Burtrum DB, Petrie HT. T cell receptor (TCR)-beta gene recombination: dissociation from cell ...